114445-41-9

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 53907-70-3 2,2,4-trimethylpent-4-en-1-ol 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 

Downstream Products

• 1094359-43-9 C₂₄H₄₀N₂O₃S 
• 1269774-74-4 1-(4-methylphenylsulfonyl)-2-nitromethyl-2,4,4-trimethylpyrrolidine 
• 1313497-27-6 C₁₅H₂₂N₂O₅S 
• 1269218-98-5 3-acetoxy-5,5-dimethyl-3-methyl-1-tosylpiperidine 
• 1380538-95-3 (S)-2-(iodomethyl)-2,4,4-trimethyl-1-tosylpyrrolidine 
• 1307916-91-1 2-(dianisylmethylmethyl)-2,4,4-trimethyl-1-tosylpyrrolidine 
• 1307916-94-4 1-(2,4,4-trimethyl-1-tosylpyrrolidin-2-yl)-2-(4-anisyl)ethane 
• 1307917-02-7 5-(2,4,4-trimethyl-1-tosylpyrrolidin-2-yl)pentan-2-one 
• 1307916-95-5 1-(2,4,4-trimethyl-1-tosylpyrrolidin-2-yl)-2-(2,3,4-trimethoxyphenyl)ethane 
• 1307916-96-6 2,4,4-trimethyl-2-{(1,2,3,4-tetrahydronaphthalen-1-yl)methyl}-1-tosylpyrrolidine 
• 1307916-97-7 1-(2,4,4-trimethyl-1-tosylpyrrolidie-2-yl)-2-anisylpropane 
• 1307917-01-6 2-(2,2-dimethyl-4-phenylbut-3-yn-1-yl)-2,4,4-trimethyl-1-tosylpyrrolidine 
• 1307916-92-2 C₂₈H₃₁Cl₂NO₂S 
• 574-42-5 benzhydryl ether 

Relevant academic research and scientific papers

Catalytic enantioselective alkene aminohalogenation/cyclization involving atom transfer

Problem solved: The title reaction was used for the synthesis of chiral 2-bromo, chloro, and iodomethyl indolines and 2-iodomethyl pyrrolidines (see scheme). Stereocenter formation is believed to occur by enantioselective cis aminocupration and C-X bond formation is believed to occur by atom transfer. The ultility of the products as versatile synthetic intermediates was demonstrated, as was a radical cascade cyclization sequence. Copyright

Radical cascade cyclizations and platinum(II)-catalyzed cycloisomerizations of ynamides

Ynamides are tested as new partners in radical and organometallic transformations. A radical cascade involving a 5-exo-dig cyclization followed by a 6-endo-trig radical trapping transforms ynamides into hetero-polycyclic compounds such as isoindoles, isoindolinones and pyrido-isoindolones. Various ene-tosylynamides react with platinum(II) chloride and lead to bicyclic nitrogenated heterocycles. This unprecedented and easily operated process can be coupled with a hydrolysis of the intermediate cyclic tosylenamides in a one-pot transformation, which provides cyclobutanones.

Platinum dichloride-catalyzed cycloisomerization of ene-ynamides

Various ene-tosylynamides react with platinum(II) chloride and lead to bicyclic nitrogenated heterocycles. This unprecedented and easily operated process can be coupled with a hydrolysis of the intermediate cyclic tosylenamides in a one-pot transformation