114474-28-1

Basic information

• Product Name: 4-(1H-Pyrazol-4-yl)aniline
• Synonyms: 4-(1H-Pyrazol-4-yl)aniline;4-(1H-pyrazol-4-yl)aniline(SALTDATA: FREE);[4-(1H-pyrazol-4-yl)phenyl]amine;MFCD11932600;4-(1H-Pyrazol-4-yl)benzenamine;4-(1H-Pyrazol-4-yl);4-(1H-Pyrazol-4-Yl)Aniline(WXC02402)
• CAS NO: 114474-28-1
• Molecular Formula: C₉H₉N₃
• Molecular Weight: 159.191
• Mol File: 114474-28-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 150-153 °C
• Boiling Point: 398.6°C at 760 mmHg
• Flash Point: 223.6°C
• Appearance: /
• Density: 1.238g/cm³
• Vapor Pressure: 1.45E-06mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.22±0.50(Predicted)
• CAS DataBase Reference: 4-(1H-Pyrazol-4-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-Pyrazol-4-yl)aniline(114474-28-1)
• EPA Substance Registry System: 4-(1H-Pyrazol-4-yl)aniline(114474-28-1)

Safety Data

• Hazardous Substances Data: 114474-28-1(Hazardous Substances Data)

Usage

General Description

4-(1H-Pyrazol-4-yl)aniline, also known as 4-phenylpyrazole, is a chemical compound with the molecular formula C9H9N3. It is a substituted aniline derivative with a pyrazole ring attached to the phenyl group. 4-(1H-Pyrazol-4-yl)aniline is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its pharmacological properties and its ability to act as a ligand for metal complexes. It is also used as an intermediate in the production of dyes and other organic compounds. 4-(1H-Pyrazol-4-yl)aniline is considered to be a potential environmental contaminant and its use and disposal should be carefully managed to prevent harm to human health and the environment.

InChI:InChI=1/C9H9N3/c10-9-3-1-7(2-4-9)8-5-11-12-6-8/h1-6H,10H2,(H,11,12)

Upstream product

• 18915-53-2 2-(4-nitrophenyl)-1,3-propanedial 
• 676605-99-5 (Z)-2-(4'-nitrophenyl)-3-N,N-dimethylaminopropenal 
• 104-03-0 4-nitrobenzeneacetic acid 
• 93072-94-7 p-Nitrophenylmalondialdehyde 
• 114474-26-9 4-(4-nitrophenyl)-1H-pyrazole 

Downstream Products

• 114474-30-5 1-[4-(1H-Pyrazol-4-yl)-phenylazo]-naphthalen-2-ylamine 

Relevant articles and documents

Monitoring the hydrogen bond net configuration and the dimensionality of aniline and phenyloxamate by adding 1: H -pyrazole and isoxazole as substituents for molecular self-recognition

This work describes the synthesis and characterization of a new class of oxamic acid derivatives containing pyrazole and isoxazole as substituents to investigate their ability to form hydrogen bonds aiming at applying them in crystal engineering and molec

BMP-SIGNAL-INHIBITING COMPOUND

The present invention relates to novel and excellent small-molecule-corn pounds that specifically antagonize BMP signal pathways, and these compounds can be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus can be used to treat diseases or pathological symptoms related to BMP signal pathway including inflammation, cardiovascular diseases, hematopoietic diseases, cancer, osteodystrophia, or the like, particularly, fibrodysplasia ossificans progressiva, and the present invention relates to provision of a pharmaceutical and pharmacological agent used for specifically antagonizing the BMP signal pathways and acting on the BMP signal pathways in the prevention and treatment or experimental application since the compounds can be beneficial for regulating cell differentiation and/or cell proliferation.

GLUCOSE UPTAKE INHIBITORS

Provided hererin are compounds that modulate glucose uptake activityand are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: Formula (I) wherein the variables have the values disclosed herein.