676605-99-5

Usage

Uses

Used in Organic Synthesis:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the creation of complex molecules.
Used in Chemical Reactions:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a reagent in chemical reactions. Its reactivity with other compounds allows for the formation of new products and the study of reaction mechanisms.
Used in Pharmaceutical Industry:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a starting material for the development of new pharmaceuticals. Its unique chemical properties make it a promising candidate for the synthesis of drugs with novel therapeutic effects.
Used in Agrochemical Industry:
(2Z)-3-Hydroxy-2-(4-nitrophenyl)acrylaldehyde is used as a precursor for the synthesis of agrochemicals. Its potential applications in this industry include the development of new pesticides, herbicides, and other agricultural chemicals.

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 555-21-5 4-Nitrophenylacetonitrile 
• 140-29-4 phenylacetonitrile 
• 85907-56-8 (Z)-3-(dimethylamino)-2-(4-nitrophenyl)acrylaldehyde 

Downstream Products

• 1448581-69-8 2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-6-sulfonic acid 
• 1448581-70-1 2-{4-[1-(pyridin-2-yl)-1H-pyrazol-4-yl]phenyl}-2H-naphtho[1,2-d][1,2,3]triazole-7-sulfonic acid 
• 1406224-43-8 4-[1-(pyridin-2-yl)-1H-pyrazol-3-yl]aniline 
• 1448581-65-4 2-[3-(4-nitrophenyl)-1H-pyrazol-1-yl]pyridine 
• 114474-28-1 4-(4-aminophenyl)-1H-pyrazole 

Relevant academic research and scientific papers

TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS

Provided are methods of treating infectious diseases in mammals comprising administering a compound that inhibits glucose uptake. Particular infectious diseases that may be treated include malaria, leishmaniasis, African trypanosomiasis, tuberculosis, HIV, HCMV or herpes virus. In a first aspect, the invention features a method of treating infectious diseases in a mammal, comprising administering to a mammalian subject in need thereof a therapeutically effective amount of a compound or prodrug thereof, or pharmaceutically acceptable salt or ester of said compound or prodrug, wherein the compound is an inhibitor of glucose uptake.

GLUCOSE UPTAKE INHIBITORS

Provided hererin are compounds that modulate glucose uptake activityand are useful for treating cancer, autoimmune diseases, inflammation, infectious diseases, and metabolic diseases. In certain embodiments, the compounds modulate glucose uptake activity by modulating cellular components, including, but not limited to those related to glycolysis and known transporters/co-transporters of glucose such as GLUT1 and other GLUT family members/alternative hexose transporters. In certain embodiments, the compounds have the structure of formula I: Formula (I) wherein the variables have the values disclosed herein.

Synthesis of novel fluorescent 2-{4-[1-(pyridine-2-yl)-1H-pyrazol-3-yl] phenyl}-2H-naphtho [1,2-d] [1,2,3] triazolyl derivatives and evaluation of their thermal and photophysical properties

Novel 2-{4-[1-(pyridine-2-yl)-1H-pyrazol-3-yl] phenyl}-2H-naphtho [1,2-d] [1,2,3] triazolyl fluorescent derivatives were synthesized from p-nitrophenylacetic acid and 2-hydrazino pyridine through Vilsmeier-Haack and diazotization reactions. Photophysical properties were evaluated, and results show that compounds have good fluorescence quantum yields. Thermal analysis showed that they are reasonably stable. The structures of the compounds were confirmed by FT-IR, 1H NMR, 13C NMR, and mass spectral and elemental analysis.

A new linker for glucuronylated anticancer prodrugs

The synthesis, enzymatic hydrolysis and self decomposition of model glucuronylated prodrugs, incorporating a new linker with different aryl substituents, have been studied. Determination of kinetic parameters (V max, Km and t1/2