18915-53-2

Usage

Uses

Used in Organic Synthesis:
2-(4-NITROPHENYL)MALONDIALDEHYDE is used as a reagent for the synthesis of various organic compounds due to its high reactivity and ability to function as a dienophile in Diels-Alder reactions.
Used in Analytical Chemistry:
2-(4-NITROPHENYL)MALONDIALDEHYDE is used as a reagent in analytical chemistry for the detection and analysis of various chemical substances.
Used in Pharmaceutical Industry:
2-(4-NITROPHENYL)MALONDIALDEHYDE is used as a research compound for studying its potential biological activities, such as its role as an apoptosis-inducing agent in cancer cells, which can contribute to the development of new drugs and therapies.
Used in Schiff Base Preparation:
2-(4-NITROPHENYL)MALONDIALDEHYDE is used as a starting material in the preparation of Schiff bases, which are important in the synthesis of various pharmaceuticals, dyes, and chemical sensors.

InChI:InChI=1/C9H7NO4/c11-5-8(6-12)7-1-3-9(4-2-7)10(13)14/h1-6,8H

Upstream product

• 104-03-0 4-nitrobenzeneacetic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 135449-94-4 6-Nitro-3-(4-nitro-phenyl)-10-thia-1,4a-diaza-anthracene 10,10-dioxide 
• 114474-26-9 4-(4-nitrophenyl)-1H-pyrazole 
• 114474-28-1 4-(4-aminophenyl)-1H-pyrazole 
• 17819-23-7 4-(4-nitrophenyl)-1,2-oxazole 
• 1033049-08-9 2-[(1E,3Z,5Z)-3-(4-nitrophenyl)-5-(3-propyl-1,3-benzothiazol-2-ylidene)penta-1,3-dienyl]-3-propyl-1,3-benzothiazol-3-ium iodide 

Relevant academic research and scientific papers

Monitoring the hydrogen bond net configuration and the dimensionality of aniline and phenyloxamate by adding 1: H -pyrazole and isoxazole as substituents for molecular self-recognition

This work describes the synthesis and characterization of a new class of oxamic acid derivatives containing pyrazole and isoxazole as substituents to investigate their ability to form hydrogen bonds aiming at applying them in crystal engineering and molec

S - Cis Diene Conformation: A New Bathochromic Shift Strategy for Near-Infrared Fluorescence Switchable Dye and the Imaging Applications

In this paper, we present a novel charge-free fluorescence-switchable near-infrared (IR) dye based on merocyanine for target specific imaging. In contrast to the typical bathochromic shift approach by extending π-conjugation, the bathochromic shift of our merocyanine dye to the near-IR region is due to an unusual S-cis diene conformer. This is the first example where a fluorescent dye adopts the stable S-cis conformation. In addition to the novel bathochromic shift mechanism, the dye exhibits fluorescence-switchable properties in response to polarity and viscosity. By incorporating a protein-specific ligand to the dye, the probes (for SNAP-tag and hCAII proteins) exhibited dramatic fluorescence increase (up to 300-fold) upon binding with its target protein. The large fluorescence enhancement, near-IR absorption/emission, and charge-free scaffold enabled no-wash and site-specific imaging of target proteins in living cells and in vivo with minimum background fluorescence. We believe that our unconventional approach for a near-IR dye with the S-cis diene conformation can lead to new strategies for the design of near-IR dyes.

Design, synthesis and biological evaluation of some novel N-arylpyrazole derivatives bearing the sulfonamide moiety as cytotoxic agents

A series of novel N-arylpyrazole derivatives (4a–4l) bearing the sulfonamide moiety were synthesized by the condensation reaction of 1,3-dicarbonyl compounds with 4-hydrazinylbenzenesulfonamide. The structures of the obtained compounds were established on

Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents

A novel series of N-arylpyrazole derivatives (5a-5d, 7a-7c) has been designed and synthesized via aromatic substitution reaction of N-nonsubstituted pyrazoles with 4-fluoronitrobenzene in the presence of base. The structures of these compounds were establ