114519-12-9

Basic information

• Product Name: L-Tyrosinamide, N-[(phenylmethoxy)carbonyl]-O-[(2,2,2-trifluoroethoxy)phosphinyl]-L-seryl -, 2,2,2-trifluoroethyl phosphonate (ester)
• CAS NO: 114519-12-9
• Molecular Formula: C24H27F6N3O10P2
• Molecular Weight: 693.43
• Mol File: 114519-12-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Tyrosinamide, N-[(phenylmethoxy)carbonyl]-O-[(2,2,2-trifluoroethoxy)phosphinyl]-L-seryl -, 2,2,2-trifluoroethyl phosphonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosinamide, N-[(phenylmethoxy)carbonyl]-O-[(2,2,2-trifluoroethoxy)phosphinyl]-L-seryl -, 2,2,2-trifluoroethyl phosphonate (ester)(114519-12-9)
• EPA Substance Registry System: L-Tyrosinamide, N-[(phenylmethoxy)carbonyl]-O-[(2,2,2-trifluoroethoxy)phosphinyl]-L-seryl -, 2,2,2-trifluoroethyl phosphonate (ester)(114519-12-9)

Safety Data

• Hazardous Substances Data: 114519-12-9(Hazardous Substances Data)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 114519-11-8 C₂₀H₂₅N₃O₁₀P₂ 
• 114519-10-7 N-(N-benzyloxycarbonyl-L-seryl)-L-tyrosine amide 
• 92466-70-1 bis(2,2,2-trifluoroethyl)phosphite 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 
• 4985-46-0 L-Tyr-NH₂ 

Downstream Products

• 114519-13-0 Z-Ser(OPO₂H₂)-Tyr(OH)NH₂ 

Relevant articles and documents

MILD BASIC AND HIGHLY SELECTIVE HYDROLYSIS OF AN ARYL-ALKYL 1-H-PHOSPHONATE DIESTER: PREPARATION OF THE MONO-1-H-PHOSPHONYLATED DIPEPTIDE Z-Ser(OPO2H2)-Tyr(OH)NH2.

Basic hydrolysis (pyridine-water) of a 2,2,2-trifluoroethyl tyrosinyl 1-H-phosphonate diester affords predominantly a 2,2,2-trifluoroethyl 1-H-phosphonate mono-ester and tyrosine.The latter finding has been applied to the synthesis of a dipeptide consisting of a 1-H-phosphonylated serine and a non-1-H-phosphonylated tyrosine moiety.