114541-98-9Relevant academic research and scientific papers
Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo
El-Achkar, Ghewa A.,Jouni, Mariam,Mrad, May F.,Hirz, Taghreed,El Hachem, Nehme,Khalaf, Ali,Hammoud, Soukaina,Fayyad-Kazan, Hussein,Eid, Assaad A.,Badran, Bassam,Merhi, Raghida Abou,Hachem, Ali,Hamade, Eva,Habib, A?da
supporting information, p. 66 - 73 (2015/02/19)
Cyclooxygenases (COXs) are important membrane-bound heme containing enzymes important in platelet activation and inflammation. COX-1 is constitutively expressed in most cells whereas COX-2 is an inducible isoform highly expressed in inflammatory condition
Synthesis of Apocynin, a Choleretic Constituent of Picrorhiza kurroa and Its Homologues
Suri, O. P.,Bindra, R. S.,Satti, N. K.,Khajuria, R. K.
, p. 587 - 588 (2007/10/02)
Apocynin (4-hydroxy-3-methoxyacetophenone) and a few of its side chain homologues have been synthesized by a simple two-step procedure.The key step in the synthesis involves Grignard reaction between vanillin acetate and different haloalkanes.The carbinols thus generated have been dehydrogenated to the desired compounds by stirring with DDQ in benzene.The synthesised compounds show consistent choleretic activity in experimental animals.
