114547-22-7

Upstream product

• 22027-96-9 5-nitroveratral 
• 6635-20-7 isonitrovanillin 

Downstream Products

• 114547-23-8 2,3-dimethoxy-5-(2-nitroethyl)aniline 
• 114547-24-9 dimethyl 2-<2,3-dimethoxy-5-(2-nitroethyl)phenylamino>but-2-enedioate 
• 114574-57-1 5-<2,3-dimethoxy-5-(2-nitroethyl)phenylaminomethylene>-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 206767-54-6 4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-1-(4-fluoro-phenyl)-6,7-dimethoxy-1H-indole-2,3-dione 
• 206767-53-5 2-{2-[3-(4-Fluoro-phenylamino)-4,5-dimethoxy-phenyl]-ethyl}-isoindole-1,3-dione 
• 206767-55-7 2-[1-(4-Fluoro-phenyl)-6,7-dimethoxy-1H-indol-4-yl]-ethylamine 
• 206767-66-0 [5-(2-Amino-ethyl)-2,3-dimethoxy-phenyl]-(4-fluoro-phenyl)-amine 
• 206767-52-4 N-[5-(2-Amino-ethyl)-2,3-dimethoxy-phenyl]-acetamide 

Relevant academic research and scientific papers

Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors

We synthesized 20 and 21 as conformationally constrained analogues of the dopamine receptor antagonist SKF-83742, as well as analogues 6-9, 16, and 18-22. Although 20 and 21 were inactive, 7, 9, and 19 showed strong binding to D-1, D-2, S-2, and α-1 receptors, as well as antipsychotic activity in vivo.

A NEW TOTAL SYNTHESIS OF AAPTAMINE

A new synthesis of the α-adrenoceptor blocker aaptamine (1) from the readily available 5-nitrovanillin is reported.An unusual intramolecular nucleophilic displacement of a nitro-group is described.