114567-01-0

Basic information

• Product Name: (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile
• Synonyms: (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile
• CAS NO: 114567-01-0
• Molecular Weight: 206.675
• Mol File: 114567-01-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile(114567-01-0)
• EPA Substance Registry System: (E)-2-(4-Chlorophenyl)-3-dimethylamino-2-propenenitrile(114567-01-0)

Safety Data

• Hazardous Substances Data: 114567-01-0(Hazardous Substances Data)

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 140-53-4 p-chlorobenzyl cyanide 

Downstream Products

• 27179-74-4 2-(4-Chlorophenyl)-2-propenenitrile 
• 134589-61-0 Sodium 2-(4-Chlorophenyl)-2-cyanoethylsulfonate 
• 125464-42-8 (+)-Saclofen 

Relevant articles and documents

The Synthesis of Phosphonobaclofen, an Antagonist of Baclofen

Phosphonobaclofen 3-amino-2-(4-chlorophenyl)propylphosphonic acid, has been synthesized in five steps from ethyl 3-(4-chlorophenyl)but-2-enoate, and is a specific antagonist of baclofen.The alternative synthetic pathways, involving conjugate addition of phosphite to 2-(4-chlorophenyl)propenenitrile and of cyanide to 2-(4-chlorophenyl)ethylphosphonate ester, failed.Cyanide ion did add efficiently to ethyl 3-(4-chlorophenyl)-2-diethoxyphosphinylprop-2-enoate and hydrogenation followed by hydrolysis of the product gave (2 S, 3 S)- and (2R, 3 R)-4-amino-3-(4-chlorophenyl)-2-phosphonobutanoic acid, which is also undergoing pharmacological evaluation.