1145979-07-2Relevant academic research and scientific papers
N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: Design, synthesis, SAR studies, and in vivo antitumor activity
Wang, Haishan,Yu, Niefang,Song, Hongyan,Chen, Dizhong,Zou, Yong,Deng, Weiping,Lye, Pek Ling,Chang, Joyce,Ng, Melvin,Sun, Eric T.,Sangthongpitag, Kanda,Wang, Xukun,Wu, Xiaofeng,Khng, Hwee Hoon,Fang, Lijuan,Goh, Siok Kun,Ong, Wai Chung,Bonday, Zahid,Stuenkel, Walter,Poulsen, Anders,Entzeroth, Michael
scheme or table, p. 1403 - 1408 (2009/10/15)
A series of N-hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides were designed and synthesized as novel HDAC inhibitors. General SAR has been established for the substituents at positions 1 and 2, as well as the importance of the ethylene group an
