1146191-40-3Relevant academic research and scientific papers
Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols
Wei, Han-Xun,Lu, Dai,Sun, Vivien,Zhang, Jing,Gu, Yongli,Osenkowski, Pamela,Ye, Wenjuan,Selkoe, Dennis J.,Wolfe, Michael S.,Augelli-Szafran, Corinne E.
, p. 2133 - 2137 (2016/04/20)
One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the beginning of a series of studies from our laboratories, a series of novel γ-amino alcohols (1) were found to possess γ-secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of γ-amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed.
SUBSTITUTED ARYL ALKYLAMINO-OXY-ANALOGYS AND THEREOF
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Page/Page column 40; 56, (2009/05/28)
Aspects of the invention relate to substituted aryl propylamino-oxy-analogs and uses thereof. Aspects of the invention relate to compositions that are inhibitors of γ-secretase and uses thereof for treating subjects having, or at risk of developing, Alzheimer's disease.
