21473-02-9

Basic information

• Product Name: 4-PHENOXYPHENYLMAGNESIUM BROMIDE
• Synonyms: 4-PHENOXYPHENYLMAGNESIUM BROMIDE;4-PHENOXYPHENYLMAGNESIUM BROMIDE, 0.5M IN SOLUTION IN TETRAHYDROFURAN;4-phenoxyphenylmagnesium bromide solution;4-Phenoxyphenylmagnesium bromide solution 0.5 in THF;4-Phenoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal;4-PhenoxyphenylMagnesiuM broMide solution 0.5 M in tetrahydrofuran;bromo-(4-phenoxyphenyl)magnesium;4-Phenoxyphenylmagnesium bromide solution 0.5M in THF
• CAS NO: 21473-02-9
• Molecular Formula: C₁₂H₉BrMgO
• Molecular Weight: 273.41
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Chemical Synthesis;Grignard Reagents;Organometallic Reagents;Grignard Reagent
• Mol File: 21473-02-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: <1 °F
• Appearance: Clear light yellow/Solution
• Density: 0.968 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Water Solubility: It reacts with water.
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: 4-PHENOXYPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENOXYPHENYLMAGNESIUM BROMIDE(21473-02-9)
• EPA Substance Registry System: 4-PHENOXYPHENYLMAGNESIUM BROMIDE(21473-02-9)

Safety Data

• Hazard Codes: F,C,Xn
• Statements: 11-19-22-34-40-36/37
• Safety Statements: 16-23-26-36/37/39-45-36/37
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• HazardClass: 3
• Hazardous Substances Data: 21473-02-9(Hazardous Substances Data)

Usage

Uses

4-Phenoxyphenylmagnesium bromide is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C12H9O.BrH.Mg/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;;/h1,3-10H;1H;/q;;+1/p-1/rC12H9BrMgO/c13-14-10-6-8-12(9-7-10)15-11-4-2-1-3-5-11/h1-9H

Upstream product

• 101-55-3 4-Bromodiphenyl ether 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 202070-31-3 1-(3-chloro-phenyl)-2,2,2-trifluoro-1-(4-phenoxy-phenyl)-ethanol 
• 41318-66-5 1,1,3-Trimethyl-1-(4-phenoxy-phenyl)-3,3-diphenyl-disiloxane 
• 18848-19-6 1,1,3,3-tetramethyl-1,3-bis-(4-phenoxy-phenyl)-disiloxane 
• 18821-66-4 1,3-Dimethyl-1,3-bis-(4-phenoxy-phenyl)-1,3-diphenyl-disiloxane 
• 6452-62-6 tetrakis-(4-phenoxy-phenyl)-stannane 
• 929018-66-6 C₂₀H₂₆O 
• 192826-62-3 2,2,2-Trifluoro-1,1-bis-(4-phenoxy-phenyl)-ethanol 
• 41318-45-0 dimethyl(4-phenoxyphenyl)(phenyl)silane 
• 18407-24-4 chloro-dimethyl-(4-phenoxy-phenyl)-silane 
• 41318-47-2 methyl(4-phenoxyphenyl)diphenylsilane 
• 17049-41-1 1-trimethylsilyl-4-phenoxybenzene 
• 944517-44-6 4-(hydroxy(4-phenoxyphenyl)methyl)benzonitrile 
• 70783-32-3 2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone 
• 129965-23-7 1,1-bis(4-phenoxyphenyl)ethylene 

Relevant articles and documents

Synthesis of trifluoromethylated α-hydroxy acids and their derivatives based on alkyl trifluoropyruvates

The reactions of trifluoropyruvates with nitromethane and arylmagnesium bromides leading to trifluoromethyl-containing α-hydroxy acid esters were studied and various derivatives of the acids were obtained.

Phenylbutanol derivatives and compositions containing them

Phenylbutanol derivatives of the formula Z--C(CH3) (OH)--CH2 --Y wherein Z is 4-biphenyl or 4-phenoxyphenyl wherein the phenoxy group is unsubstituted or substituted by F, Cl or Br and Y is COOR2 or CH2 OR3 wherein R2 is H or alkyl of 1 to 6 carbon atoms and R3 is H or alkanoyl of 1 to 6 carbon atoms, and their physiologically acceptable salts, possess anti-inflammatory activity and are produced by (a) treating with a solvolyzing agent a compound of the formula Z--C(CH3) (OH)--CH2 --W or Z--CX(CH3)--CH2 --Y wherein W is a functionally modified carboxy or methylol group different from Y and X is Cl, Br or I or a functionally modified hydroxyl group; or (b) reducing a compound otherwise corresponding to a desired final product but having instead of one of the hydrogen atoms a group which can be reduced or replaced by a hydrogen atom; or (c) oxidizing a compound otherwise corresponding to a desired final product but lacking the tertiary hydroxyl group; or (d) converting a compound otherwise corresponding to a desired final product wherein Z is a 4-phenoxyphenyl group but having instead a 4--OH--, Cl--, Br-- or I-substituted phenyl group into a desired final product; or (e) diazotizing a compound otherwise corresponding to a desired final product wherein Z is a halogen-substituted 4-phenoxyphenyl group but having an --NH2 -substituted phenoxy group and reacting the resulting diazonium salt with a halogenating agent.