21473-02-9

Basic information

• Product Name: 4-PHENOXYPHENYLMAGNESIUM BROMIDE
• Synonyms: 4-PHENOXYPHENYLMAGNESIUM BROMIDE;4-PHENOXYPHENYLMAGNESIUM BROMIDE, 0.5M IN SOLUTION IN TETRAHYDROFURAN;4-phenoxyphenylmagnesium bromide solution;4-Phenoxyphenylmagnesium bromide solution 0.5 in THF;4-Phenoxyphenylmagnesium bromide, 0.5M solution in THF, AcroSeal;4-PhenoxyphenylMagnesiuM broMide solution 0.5 M in tetrahydrofuran;bromo-(4-phenoxyphenyl)magnesium;4-Phenoxyphenylmagnesium bromide solution 0.5M in THF
• CAS NO: 21473-02-9
• Molecular Formula: C₁₂H₉BrMgO
• Molecular Weight: 273.41
• Product Categories: Aryl;Grignard Reagents;Organometallic Reagents;Chemical Synthesis;Grignard Reagents;Organometallic Reagents;Grignard Reagent
• Mol File: 21473-02-9.mol

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: <1 °F
• Appearance: Clear light yellow/Solution
• Density: 0.968 g/mL at 25 °C
• Storage Temp.: 2-8°C
• Water Solubility: It reacts with water.
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: 4-PHENOXYPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENOXYPHENYLMAGNESIUM BROMIDE(21473-02-9)
• EPA Substance Registry System: 4-PHENOXYPHENYLMAGNESIUM BROMIDE(21473-02-9)

Safety Data

• Hazard Codes: F,C,Xn
• Statements: 11-19-22-34-40-36/37
• Safety Statements: 16-23-26-36/37/39-45-36/37
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• HazardClass: 3
• Hazardous Substances Data: 21473-02-9(Hazardous Substances Data)

Usage

Uses

4-Phenoxyphenylmagnesium bromide is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C12H9O.BrH.Mg/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;;/h1,3-10H;1H;/q;;+1/p-1/rC12H9BrMgO/c13-14-10-6-8-12(9-7-10)15-11-4-2-1-3-5-11/h1-9H

Upstream product

• 101-55-3 4-Bromodiphenyl ether 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 129965-23-7 1,1-bis(4-phenoxyphenyl)ethylene 
• 17049-41-1 1-trimethylsilyl-4-phenoxybenzene 
• 41318-47-2 methyl(4-phenoxyphenyl)diphenylsilane 
• 41318-45-0 dimethyl(4-phenoxyphenyl)(phenyl)silane 
• 202070-31-3 1-(3-chloro-phenyl)-2,2,2-trifluoro-1-(4-phenoxy-phenyl)-ethanol 
• 202604-70-4 N-benzyl-4-(4-phenoxyphenyl)-4-piperidinol 
• 2653-93-2 1-phenoxy-4-(prop-2-en-1-yl)benzene 
• 6452-62-6 tetrakis-(4-phenoxy-phenyl)-stannane 
• 1227160-97-5 ethyl 2,2-difluoro-2-(4-phenoxyphenyl)acetate 
• 18670-69-4 Chloro-methyl-(4-phenoxy-phenyl)-phenyl-silane 
• 18407-24-4 chloro-dimethyl-(4-phenoxy-phenyl)-silane 
• 41318-65-4 C₃₀H₃₆O₄Si₃ 
• 944517-44-6 4-(hydroxy(4-phenoxyphenyl)methyl)benzonitrile 
• 70783-32-3 2,2,2-trifluoro-1-(4-phenoxyphenyl)-ethanone 

Relevant articles and documents

Synthesis of trifluoromethylated α-hydroxy acids and their derivatives based on alkyl trifluoropyruvates

The reactions of trifluoropyruvates with nitromethane and arylmagnesium bromides leading to trifluoromethyl-containing α-hydroxy acid esters were studied and various derivatives of the acids were obtained.

Arylpiperidinopropanol and arylpiperazinopropanol derivatives and pharmaceuticals containing the same

A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: wherein R1to R4independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R5represents H, optionally substituted alkyl, aryl, or aralkyl group, E1represents O, S, or —NR6, where R6represents H, an optionally substituted alkyl, aryl, or aralkyl group, E2represents O, S, or —NR7, where R7represents H, an optionally substituted alkyl, aryl, or aralkyl group, A represents CH, C(OH), or N, X represents H, halogen, alkoxy, or an optionally substituted alkyl group, and Q represents an optionally substituted phenyl group, phenoxy, phenylmethyl, or cycloalkyloxy group, where when E1represents O or S, E2does not represent O or S, which has an action of suppressing the cytotoxic Ca2+overload and lipid peroxidation and effective for pharmaceutical preparation for the alleviation and treatment of symptoms due to ischemic diseases, etc.

Phenylbutanol derivatives and compositions containing them

Phenylbutanol derivatives of the formula Z--C(CH3) (OH)--CH2 --Y wherein Z is 4-biphenyl or 4-phenoxyphenyl wherein the phenoxy group is unsubstituted or substituted by F, Cl or Br and Y is COOR2 or CH2 OR3 wherein R2 is H or alkyl of 1 to 6 carbon atoms and R3 is H or alkanoyl of 1 to 6 carbon atoms, and their physiologically acceptable salts, possess anti-inflammatory activity and are produced by (a) treating with a solvolyzing agent a compound of the formula Z--C(CH3) (OH)--CH2 --W or Z--CX(CH3)--CH2 --Y wherein W is a functionally modified carboxy or methylol group different from Y and X is Cl, Br or I or a functionally modified hydroxyl group; or (b) reducing a compound otherwise corresponding to a desired final product but having instead of one of the hydrogen atoms a group which can be reduced or replaced by a hydrogen atom; or (c) oxidizing a compound otherwise corresponding to a desired final product but lacking the tertiary hydroxyl group; or (d) converting a compound otherwise corresponding to a desired final product wherein Z is a 4-phenoxyphenyl group but having instead a 4--OH--, Cl--, Br-- or I-substituted phenyl group into a desired final product; or (e) diazotizing a compound otherwise corresponding to a desired final product wherein Z is a halogen-substituted 4-phenoxyphenyl group but having an --NH2 -substituted phenoxy group and reacting the resulting diazonium salt with a halogenating agent.