117856-46-9

Upstream product

• 117856-44-7 1-benzyl-3-<3'-(diphenyl-t-butylsilyloxy)propyl>-5-methoxy-3,6-dihydropyrazin-2(1H)-one 
• 114671-83-9 1-(t-butyldiphenylsilyloxy)-3-iodopropane 
• 59595-20-9 4-benzylpiperazin-2,5-dione 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 104124-14-3 1-benzyl-5-methoxy-3,6-dihydropyrazin-2(1H)-one 

Downstream Products

• 78999-51-6 spiro 
• 117856-47-0 1-benzyl-3-(3'-hydroxypropyl)-5-methoxypyrazin-2(1H)-one 

Relevant academic research and scientific papers

Synthetic Studies on Bicyclomycin and its Analogues. Part 1. Synthesis of Substituted 2-Oxa-8,10-diazabicyclodecanes

Methods have been developed for formation of the eight-membered oxygen-containing ring system (2) present in the antibiotic bicyclomycin.The procedure starts with N,N'-disubstituted piperazine-2,5-diones or the corresponding mono imino ethers.A new method is based on the oxidation of the mono imino ethers using 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) as oxidant: the bis imino ethers gave pyrazines under these conditions, whilst the parent piperazinedione proved to be unreactive.