1146963-53-2

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 109-94-4 formic acid ethyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 64-18-6 formic acid 
• 124-38-9 carbon dioxide 
• 459-46-1 4-Fluorobenzyl bromide 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Relevant academic research and scientific papers

Tribromo melamine as novel and versatile catalyst for the formylation and acetylation of alcohols

Tribromo melamine has been found to be an efficient and green organocatalyst for the acetylation and formylation reactions of alcohols with acetic anhydride and ethyl formate at room temperature and under mild reaction conditions.

Making Carbonyls of Amides Nucleophilic and Hydroxyls of Alcohols Electrophilic Mediated by SO2F2 for Synthesis of Esters from Amides

We discovered that with the promotion of sulfuryl fluoride, the carbonyl groups of amides performed as nucleophiles while the hydroxyl groups of alcohols were activated to functionalize as electrophiles. This study displayed that the amide C-N bonds could be easily cleaved with delicate nucleophiles to form the ester C-O bonds at room temperature without using transition metals. The broad substrate scope and excellent functional group compatibility were proved with 44 examples in up to 99% yields.

Photocatalytic Chemical CO2 Fixation by Cu-BDC Nanosheet?Macroporous-Mesoporous-TiO2 under Mild Conditions

Growing greenhouse gas CO2 is driving the research on the chemical fixation of CO2. Here, the organic reaction of CO2 with benzyl halogen for chemical CO2 fixation under ambient conditions with irradiation of ultraviolet light is successfully catalyzed by Cu-BDC nanosheet?macroporous-mesoporous-TiO2 (Cu-BDC?macro-meso-TiO2), which shows high photocatalytic activity for both benzyl chloride and bromide reacting with CO2. Meanwhile, the prepared Cu-BDC?macro-meso-TiO2 possesses a three-scale porous structure, including macropores, mesopores, and micropores. In the uniform hierarchical structure, the microporous Cu-BDC nanosheet is confined in the macropore of macroporous-mesoporous-TiO2, while the ordered mesoporous structure is in the macroporous walls. This multilevel porous distribution can significantly improve the active surface areas and mass transfer efficiency of Cu-BDC?macro-meso-TiO2. Therefore, this finding has opened a field of research on photocatalytic chemical CO2 fixation.

Method for preparing formate-type compound

The invention discloses a method for preparing a formate-type compound. The method comprises the following steps of: adopting an alcohol-type compound and 1,3-dihydroxyacetone as reaction raw materials, and under the existence of a composite catalyst and an oxidant, reacting for 2-48 hours in a reaction medium in a reactor at a reaction temperature of 25-100 DEG C so as to obtain the formate-typecompound. The method disclosed by the invention is simple, and is mild in reaction condition, and by the method, a target product can be obtained by low cost and high yield; the used catalyst has highcatalytic activity, and is easily separated from a reaction system to be repeatedly used; the whole process is environment-friendly, and the reaction raw material (1,3-dihydroxyacetone) is easily converted from a side product (glycerol) of biodiesel, so that the utilization of the glycerol is promoted.

P-Toluenesulfonyl chloride as a new and effective catalyst for acetylation and formylation of hydroxyl compounds under mild conditions

The catalytic application of p-toluenesulfonyl chloride for efficient acetylation of various types of alcohols and phenols with acetic anhydride in solvent-free conditions is reported. Also structurally diverse alcohols were formylated using formic acid based on the use of catalytic amount of p-toluenesulfonyl chloride under solvent-free condition. The reactions were carried out in short reaction time and in good to excellent yields at room temperature.

Silica sulfuric acid and AI(HSO4)3: As efficient catalysts for the formylation of alcohols by using ethyl formate under heterogeneous conditions

A mixture of ethyl formate and a catalytic amount of silica sulfuric acid or Al(HSO4)3 as suitable formylating systems can formylate various alcohols to their corresponding formate ester derivatives under mild, nearly neutral and heterogeneous conditions at room temperature with good to excellent yields.