1146972-70-4

Basic information

• Product Name: 1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole
• Synonyms: 1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole
• CAS NO: 1146972-70-4
• Molecular Weight: 388.444
• Mol File: 1146972-70-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole(1146972-70-4)
• EPA Substance Registry System: 1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole(1146972-70-4)

Safety Data

• Hazardous Substances Data: 1146972-70-4(Hazardous Substances Data)

Upstream product

• 93-26-5 2-methoxyacetanilide 
• 21987-25-7 5-methoxy-3-methyl-1H-indole 
• 3746-67-6 3-(acetylamino)-4-methoxybenzensulfonyl chloride 

Downstream Products

• 1146972-71-5 1-(3'-amino-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole 
• 1146972-62-4 N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylpropane-1,3-diamine 
• 1146972-28-2 N'-[2-methoxy-5-(5-methoxy-3-methylindole-1-sulfonyl)phenyl]-N,N-dimethylethane-1,2-diamine 

Relevant articles and documents

Design, synthesis and pharmacological evaluation of indolylsulfonamide amines as potent and selective 5-HT6 receptor antagonists

A series of N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl ethane-1,2-diamines and N′-[3-(indole-1-sulfonyl) aryl]-N,N-dimethyl propane-1,3-diamines was designed and synthesized as 5-HT6 receptor ligands. These compounds, when screened in a functional reporter gene-based assay, displayed potent antagonistic activity with Kb values in the range of 1.8-60 nM. The lead compound 9y has shown good ADME surrogate properties, acceptable pharmacokinetic profile and is active in animal models of cognition like novel object recognition test and Morris water maze. It was selected for detailed profiling.

AMINO ARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS FIELD OF INVENTION

The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention