1146973-47-8

Basic information

• Product Name: 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine
• Synonyms: 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine
• CAS NO: 1146973-47-8
• Molecular Weight: 338.332
• Mol File: 1146973-47-8.mol

Chemical Properties

• CAS DataBase Reference: 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine(1146973-47-8)
• EPA Substance Registry System: 3-phenyl-1-(4-(trifluoromethyl)phenyl)imidazo[1,5-a]pyridine(1146973-47-8)

Safety Data

• Hazardous Substances Data: 1146973-47-8(Hazardous Substances Data)

Upstream product

• 1021417-83-3 1-(pyridin-2-yl)-1-(4-trifluoromethylphenyl)methylamine 
• 100-52-7 benzaldehyde 
• 2835-06-5 phenylglycin 
• 122377-19-9 (pyridin-2-yl)(4-(trifluoromethyl)phenyl)methanone 
• 100-46-9 benzylamine 
• 100-70-9 2-Cyanopyridine 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 591-50-4 iodobenzene 
• 35854-46-7 3-phenylimidazo[1,5-a]pyridine 
• 455-13-0 4-Iodobenzotrifluoride 
• 274-47-5 imidazo[1,5-a]pyridine 

Relevant articles and documents

Synthesis of 1,3-Disubstituted Imidazo[1,5-a]pyridines from Amino Acids via Catalytic Decarboxylative Intramolecular Cyclization

A copper/iodine cocatalyzed decarboxylative cyclization of α-amino acids is described. Starting from the readily available amino acids and either 2-benzoylpyridines or 2-benzoylquinolines, 1,3-disubstituted imidazo[1,5-a]pyridines and 1,3-disubstituted im

Heterogeneous copper-catalyzed decarboxylative cyclization of 2-benzoylpyridines with α-amino acids leading to imidazo[1,5-a]pyridines

The heterogeneous decarboxylative cyclization reaction between 2-benzoylpyridines and α-amino acids was achieved in toluene at 120 °C in the presence of 15 mol% of L-proline-functionalized MCM-41-supported copper(II) complex [L-Proline-MCM-41-Cu(OTf)

Copper-catalyzed oxidative amination of sp3 C-h bonds under air: Synthesis of 1,3-diarylated imidazo[1,5-a ]pyridines

A copper(II)-catalyzed tandem reaction between pyridine ketone and benzylamine was developed by using clean O2 as an oxidant. This transformation proceeded via an efficient condensation-amination-oxidative dehydrogenation process, affording 1,3-diarylated imidazo[1,5-a]pyridines in excellent yields.

Direct sequential C3 and C1 arylation reaction of imidazo[1,5-a]pyridine catalyzed by a 1,10-phenanthrolinepalladium complex

The direct sequential arylation reaction at the C3 and C1 positions of imidazo[1,5-a]pyridines with a variety of aryl iodides catalyzed by [Pd(phen)2](PF6)2 is described. The reaction of unsubstituted imidazo[1,5-a]pyridine with various aryl iodides proceeded selectively at the C3 position to exclusively give the corresponding C3-arylated products. The one-pot double-arylation reaction at the C3 and C1 positions of unsubstituted imidazo[1,5-a]pyridine with different aryl groups was also achieved.

Synthesis of fluorescent 1,3-diarylated imidazo[1,5-α]pyridines: Oxidative condensation-cyclization of aryl-2-pyridylmethylamines and aldehydes with elemental sulfur as an oxidant

Oxidative condensation - cyclization of aldehydes and aryl-2- pyridylmethylamines proceeded in the presence of a stoichiometric amount of elemental sulfur as an oxidant in the absence of catalyst. The reaction gave a variety of 1,3-diarylated imidazo[l,5-a]pyridines in good to high yields. The products showed fluorescence emission in a wavelength range of 454-524 nm. The quantum yields of 1,3-diarylated imidazopyridines were greatly improved compared to those of the parent 3-monosubstituted compounds.