114701-05-2Relevant academic research and scientific papers
HYDROXYMORPHOLINONE DERIVATIVE AND MEDICINAL USE THEREOF
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Page 21, (2010/02/09)
A compound represented by the following formula (I) wherein R1 and R2 are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof is provided.
Novel 6-Hydroxy-3-morpholinones as cornea permeable calpain inhibitors
Nakamura, Masayuki,Miyashita, Hiroyuki,Yamaguchi, Masazumi,Shirasaki, Yoshihisa,Nakamura, Yoshikuni,Inoue, Jun
, p. 5449 - 5460 (2007/10/03)
A novel series of 6-hydroxy-3-morpholinones, in which the functional aldehyde and the hydroxy group of P2 site form a cyclic hemiacetal, was identified as calpain inhibitors. The placement of isobutyl group at the 2-position of the 3-morpholino
Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle
Guillaumie,Kappel,Kelly,Barany,Jensen
, p. 6131 - 6135 (2007/10/03)
Peptide aldehydes were synthesized, starting from amino acetals, by a Solid-phase backbone amide linker (BAL) strategy. (C) 2000 Elsevier Science Ltd.
DIASTEREOSELECTIVE SYNTHESIS OF 2,3-CIS-2-ALKYL-3-OXYGENATED PIPERIDINE DERIVATIVES BY TITANIUM MEDIATED INTRAMOLECULAR CYCLIZATION OF α-AMINOACETAL-ALLYLSILANE SYSTEM
Kano, Shinzo,Yokomatsu, Tsutomu,Iwasawa, Haruo,Shibuya, Shiroshi
, p. 2805 - 2809 (2007/10/02)
(2S,3S)-2-Alkyl-3-oxygenated 5-methylenepiperidines were obtained with high diastereoselectivity by cyclization of N-methoxycarbonyl-N-silylmethallyl-α-alkylaminoacetaldehyde ethyleneacetals with TiCl3(OPri).
