114702-17-9Relevant academic research and scientific papers
Regioselective Pd-catalyzed alkylative lactonizations of 4-hydroxy-2-alkynecarboxylates with organoboronic acids
Oh, Chang Ho,Park, Su Jin,Ryu, Jin Hyang,Gupta, Arun Kumar
, p. 7039 - 7042 (2007/10/03)
The Pd-catalyzed addition of organoboronic acids to 4-hydroxy-2- alkynecarboxylates and in situ lactonization gave the butenolides with a high control of regioselectivity.
THE PALLADIUM -TRIBUTYL FORMATE REAGENT IN THE STEREOSELECTIVE HYDROGENATION, AND STEREO- AND REGIOSELECTIVE HYDROARYLATION OF ALKYL 4-HYDROXY-2-ALKYNOATES: A ROUTE TO SUBSTITUTED BUTENOLIDES
Arcadi, A.,Bernocchi, E.,Burini, A.,Cacchi, S.,Marinelli, F.,Pietroni, B.
, p. 481 - 490 (2007/10/02)
The reaction of aryl iodides with alkyl 4-hydroxy-2-alkynoates in the presence of formic acid, tri-n-butylamine and a palladium(II) catalyst provides a convenient route to functionalized substituted butenolides through a one pot hydroarylation/cyclization reaction.In the presence of formic acid, tri-n-butylamine and a palladium(II) catalyst, alkyl 4-hydroxy-2-alkynoates undergo a one pot hydrogenation/cyclization reaction to the butenolide ring.By increasing the excess of formic acid, direct formation of saturated γ-lactones can be observed.Reaction occur with high stereoselectivity and, in the case of the hydroarylation, with goog regioselectivity.
