25294-59-1

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 115-19-5 2-methyl-but-3-yn-2-ol 

Downstream Products

• 98017-91-5 trans-4-Hydroxy-4-methyl-3-phenoxy-penten-⁽²⁾-saeure-methylester 
• 114702-18-0 3-(4-Hydroxy-phenyl)-5,5-dimethyl-5H-furan-2-one 
• 114702-17-9 3-(4-Methoxy-phenyl)-5,5-dimethyl-5H-furan-2-one 
• 133055-36-4 4-(4-Chloro-benzenesulfinyloxy)-4-methyl-pent-2-ynoic acid methyl ester 
• 114702-19-1 3-(3-Hydroxymethyl-phenyl)-5,5-dimethyl-5H-furan-2-one 
• 130884-26-3 methyl 4-methyl-2-(phenylsulfinyl)penta-2,3-dienoate 
• 133055-31-9 Methyl 2-(4-Chlorophenylsulfinyl)-4-methyl-2,3-pentadienoate 
• 22621-30-3 4-hydroxy-5,5-dimethyl-5H-furan-2-one 
• 133055-33-1 Methyl 4-Methyl-2-(phenylthio)-2,3-pentadienoate 
• 133055-32-0 Methyl 2-<(4-Chlorophenyl)thio>-4-methyl-2,3-pentadienoate 
• 130884-28-5 methyl 4-methyl-2-(phenylsulfonyl)penta-2,3-dienoate 
• 130884-45-6 methyl 2-(4-chlorophenylsulfonyl)-4-methyl-penta-2,3-dienoate 
• 91910-27-9 4-Methyl-3-phenoxy-pentadien-(2,4)-saeure-methylester 
• 91963-34-7 4-Methyl-3-phenoxy-pentadien-(2,4)-saeure 

Relevant academic research and scientific papers

Methoxycarbonylation of Acetylenic Compounds

A one-step procedure was developed for preparation of α,β-acetylenic γ-hydroxycarboxylic acid methyl esters with high yields by methoxycarbonylation of acetylenic alcohols with carbon monoxide in the presence of the catalytic system PdCl2-CuCl2-NaOAc (molar ratio methanol-acetylenic alcohol-PdCl2-CuCl2-NaOAc 5:0.02:0.0006:0.07:0.07). Methyl 4-methyl-4-hydroxy-2-pentynoate can be synthesized in the presence of CuCl2-NaOAc with no palladium.