114710-73-5Relevant articles and documents
Influence of Substituents on the Synthesis of Thiazolidinones
Sabu, M.,Garnaik, B. K.,Behera, Rajani K.
, p. 779 - 781 (2007/10/02)
The influence of substituents (subunits) in the synthesis of thiazolidinones by the reaction of unsymmetrical thioureas with monochloroacetic acid in ethanol has been rationalised by the characterisation of the hydrolysis products of the resulting thiazolidinones.The formation of thiol from thiourea, which is the key intermediate in thiazolidinone synthesis, invariably involves the -NH- group adjacent to more electron withdrawing subunits.