114738-04-4Relevant articles and documents
The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter
Wang, Shengyang,Zhang, Qingju,Zhao, Yachen,Sun, Jiansong,Kang, Wenjia,Wang, Fei,Pan, Haixue,Tang, Gongli,Yu, Biao
, p. 10558 - 10562 (2019)
The structural puzzle of amipurimycin, a peptidyl nucleoside antibiotic, is solved by total synthesis and X-ray diffraction analysis, with the originally proposed configurations at C3′ and C8′ inverted and those at C6′, C2′′, and C3′′ corrected. A similar structural revision of the relevant miharamycins is proposed via chemical transformations and then validated by X-ray diffraction analysis. The miharamycins bear an unusual trans-fused dioxabicyclo[4.3.0]nonane sugar scaffold, which was previously assigned as being in the cis configuration.
Elongation of the side chain by linear alkyl groups increases the potency of salacinol, a potent α-glucosidase inhibitor from the Ayurvedic traditional medicine “Salacia,” against human intestinal maltase
Takashima, Katsuki,Sakano, Mika,Kinouchi, Eri,Nakamura, Shinya,Marumoto, Shinsuke,Ishikawa, Fumihiro,Ninomiya, Kiyofumi,Nakanishi, Isao,Morikawa, Toshio,Tanabe, Genzoh
, (2021)
Four chain-extended analogs (12a–12d) and two related de-O-sulfonated analogs (13a and 13c) by introducing alkyl groups (a: R = C3H7, b R = C6H13, c: R = C8H17, d: R = C10H2
CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF
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, (2021/11/05)
Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.
CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS
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, (2019/02/13)
The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
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, (2016/08/07)
The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
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, (2016/03/08)
Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.
NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND USES RELATED THERETO
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, (2015/03/28)
This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five
Cipolla, Laura,Airoldi, Cristina,Sperandeo, Paola,Gianera, Serena,Polissi, Alessandra,Nicotra, Francesco,Gabrielli, Luca
, p. 186 - 191 (2014/05/20)
A set of new metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at position 5 was synthesised. Their ability to interact with arabinose 5-phosphate isomerase from Pseudomonas aeruginosa was evaluated by STD-NMR studie
Phosphonate analogues of arabinose 5-phosphate: Putative ligands for arabinose 5-phosphate isomerases
Gabrielli, Luca,Airoldi, Cristina,Sperandeo, Paola,Gianera, Serena,Polissi, Alessandra,Nicotra, Francesco,Cipolla, Laura
, p. 7776 - 7784 (2013/12/04)
Metabolically stable arabinose 5-phosphate analogues possessing phosphate mimetic groups at the 5-position were synthesized and evaluated by saturation-transfer-difference (STD) NMR studies for their ability to interact with arabinose 5-phosphate isomeras
A POSITRON EMISSION TOMOGRAPHY PROBE TO MONITOR SELECTED SUGAR METABOLISM IN VIVO
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Page/Page column 24, (2013/12/03)
The invention disclosed herein discloses selected ribose isomers that are useful as PET probes (e.g. [18F]-2-fluoro-2-deoxy-arabinose). These PET probes are useful, for example, in methods designed to monitor physiological processes including ribose metab