114740-63-5

Upstream product

• 110-89-4 piperidine 
• 64-17-5 ethanol 
• 117506-45-3 2-(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)propanedinitrile 
• 108-26-9 3-methyl-2-pyrazoline-5-one 
• 606-23-5 1H-indene-1,3(2H)-dione 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 89-25-8 edaravone 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 135312-91-3 Methyl 2-(2-Bromotetradecanamido)dodecanoate 

Relevant academic research and scientific papers

Structural reassignment of an 'unusual' derivative of 3-methyl-5-phenylpyrazol-5-one (Edaravone)

The structure of the major product from the reaction of 4-bromo-3-methyl-1-phenylpyrazol-5-one (1) with ethyl cyanoacetate is shown, by means of an X-ray crystal structure determination, to be the spirocyclic compound 4, rather than the previously propose

Reaction of 2-(3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene) propanedinitrile with 1,3-dicarbonyl compounds

2-(3-Methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene) propanedinitrile (1) reacted with indane-1,3-dione (2) to give 2-amino-3'-methyl-5,5'-dioxo- 1'-phenylspiro[indeno[1,2-b]pyran-4(5H),4'(5'H)-[1H]pyrazole]-3-carbonitrile (3), 6-amino-3,3'-dimethyl-5'-oxo-1,1'-diphenylspiro[pyrano[2,3-c]pyrazole- 4(1H),4'(5'H)-1[1H]pyrazole]-5-carbonitrile (6) and 2'-amino-1,3,5'- trioxospiro[indane-2,4'(5'H)-indeno[1,2b]pyran]-3'-carbonitrile (7). Also 1 reacted with 4-hydroxy-2H-chromen-2-one (8) to afford 2-amino-3'-methyl- 5,5'-dioxo-1'-phenylspiro[4H, 5H-pyrano-[3,2c]-1-chromene-4,4'(5'H)- [1H]pyrazole]3-carbonitrile (9) together with 6. While 5,5- dimethylcyclohexane-1,3-dione (11) reacted with 1 to give 2-amino-3',7,7- trimethyl-5,5'-dioxo-1'-phenyl-5,6,7,8-tetrahydrospiro[4H-chromene-4,4'(5'H)- [1H]pyrazole]-3-carbonitrile (12) as a solely product.

Reactions of 4-(Dicyanomethylene)-3-methyl-1-phenyl-2-pyrazolin-5-one towards Active Methylene Compounds

The reaction of some active methylene compounds with 4-(dicyanomethylene)-3-methyl-1-phenyl-2-pyrazolin-5-one (1a) has been investigated.This reaction involves a Michael addition to afford 4-spirocyclobutenes 3 or cyclopyran-2-pyrazolin-5-ones 4, dependin

Synthesis and Structure Elucidation of γ-Aminobutyric Acid Conjugates with Lipidic Acids, Lipidic Amino Acids and Lipidic Peptides

A series of γ-aminobutyric acid esters of lipidic acids, lipidic peptides and γ-aminobutyric acid amides of lipidic α-amino acids and oligomers were synthesised.The GABA conjugates with ester linkages (6j-r) were prepared by coupling the lipidic acids and peptide conjugates to the carboxyl terminus of GABA.Two types of GABA conjugates linked by amide bonds were synthesised.This class included compounds 5d-f in which the amino group of the lipidic amino acid is condensed with the carboxyl function of GABA and compounds 7a-b with the carboxyl terminus of the α-amino acid coupled to the amino group of GABA.The lipidic amino acid peptide oligomers were varied from 1-3 units, and the alkyl side chains ranged from 5-17 carbon atoms in length in order to impart different lipophilicities to the GABA molecule conjugates. Key Words: Amino acids, fatty / Peptides, lipidic / Lipophilic GABA conjugates / Drug delivery