114744-95-5Relevant academic research and scientific papers
Synthesis of enantiopure syn-β-amino alcohols. A simple case of chelation-controlled additions of diethylzinc to α-(dibenzylamino) aldehydes
Andres, Jose M.,Barrio, Roberto,Martinez, Maria A.,Pedrosa, Rafael,Perez-Encabo, Alfonso
, p. 4210 - 4213 (2007/10/03)
Enantiomerically pure syn-2-amino alcohols 6 are prepared by addition of diethylzinc to chiral α-(dibenzylamino) aldehydes 4. The addition is highly stereoselective, leading to syn-2-(dibenzylamino) alcohols 5 with excellent diastereomeric excesses (76-98%). Debenzylation of 5 by hydrogenolysis on Pearlman's catalyst yields quantitatively the amino alcohols 6.
A NEW FACILE DIASTEREOCONVERSION OF 2-AMINO ALCOHOLS INVOLVING A NOVEL CYCLOCARBAMATION
Kano, Shinzo,Yokomatsu, Tsutomu,Iwasawa, Haruo,Shibuya, Shiroshi
, p. 6331 - 6334 (2007/10/02)
A new practical method for diastereoconversion of 2-amino alcohols was performed by treatment on N-Cbz- derivatives with trifluoromethanesulfonic anhydride or thionyl chloride, followed by ring cleavage of the resulting oxazolidin-2-ones
