114747-32-9

Upstream product

• 108-94-1 cyclohexanone 
• 77375-19-0 2,3-dimethyl-4-methoxyaniline 
• 2011-57-6 N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide 
• 74783-54-3 1-hydroxy-2,3-dimethyl-4-nitrosobenzene 
• 3096-69-3 4-amino-2,3-dimethylphenol 
• 526-75-0 2,3-Dimethylphenol 

Relevant academic research and scientific papers

Short Syntheses of 4-Deoxycarbazomycin B, Sorazolon E, and (+)-Sorazolon E2

Short syntheses of 4-deoxycarbazomycin B and sorazolon E were established through the condensation of cyclohexanone and commercially available 4-methoxy-2,3-dimethylaniline, followed by PdII-catalyzed dehydrogenative aromatization/intramolecular C?C bond coupling and deprotection. A chiral dinuclear vanadium complex (Ra,S,S)-6 mediated the enantioselective oxidative coupling of sorazolon E, affording (+)-sorazolon E2 in good enantioselectivity.

Synthesis of 4-deoxycarbazomycin B: A convenient alternative

4-Deoxycarbazomycin B(3) was synthesized by condensation of 4-methoxy-2,3-dimethylacetanilide (8) with bromobenzene in presence of cuprous iodide and potassium carbonate, and subsequent hydrolysis with 20% aqueous ethanolic KOH, followed by cyclisation of the resulting substituted diphenylamine (9) with palladium acetate in acetic acid.