3096-69-3

Basic information

• Product Name: 4-AMINO-2,3-XYLENOL
• Synonyms: 4-AMINO-2,3-XYLENOL;2,3-DIMETHYL-4-AMINOPHENOL;4-amino-2,3-dimethylphenol;4-hydroxy-2,3-dimethylaniline;4-AMINO-2,3-XYLENOL 97+%;4-azanyl-2,3-dimethyl-phenol;4-Amino-2,3-dimethylphenol 4-Hydroxy-2,3-dimethylaniline
• CAS NO: 3096-69-3
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• EINECS: 221-446-4
• Mol File: 3096-69-3.mol

Chemical Properties

• Melting Point: 174°C
• Boiling Point: 296.3 °C at 760 mmHg
• Flash Point: 133 °C
• Appearance: /
• Density: 1.118 g/cm³
• Vapor Pressure: 0.00082mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 4-AMINO-2,3-XYLENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2,3-XYLENOL(3096-69-3)
• EPA Substance Registry System: 4-AMINO-2,3-XYLENOL(3096-69-3)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 3096-69-3(Hazardous Substances Data)

Usage

Uses

Used in Cosmetic Industry:
4-AMINO-2,3-XYLENOL is used as a colorant for its ability to impart rich and vibrant colors to hair. It is particularly favored for its effectiveness in hair dyes and hair care products, where it enhances the visual appeal and provides a natural-looking color to the hair.
Used in Hair Dye Formulation:
In hair dyes, 4-AMINO-2,3-XYLENOL is used as an active ingredient to deliver the desired shade and depth of color. Its chemical properties allow for a wide range of color options, making it a versatile component in the formulation of various hair dye products.
Used in Hair Care Products:
Beyond its color-enhancing properties, 4-AMINO-2,3-XYLENOL is also used in hair care products for its conditioning and nourishing effects. It helps to maintain the health and integrity of the hair, providing a smoother texture and reducing frizz, which contributes to the overall manageability and appearance of the hair.
Used in Conditioning Treatments:
4-AMINO-2,3-XYLENOL can be found in conditioning treatments designed to improve the hair's condition after coloring or other chemical processes. Its presence in these treatments helps to restore moisture, reduce breakage, and enhance the overall health of the hair.
Used in Hair Styling Products:
In addition to hair dyes and care products, 4-AMINO-2,3-XYLENOL may also be incorporated into hair styling products to provide temporary color enhancement and improve the manageability of the hair during styling.

InChI:InChI=1/C8H11NO/c1-5-6(2)8(10)4-3-7(5)9/h3-4,10H,9H2,1-2H3

Upstream product

• 3096-62-6 N-(2,3-dimethylphenyl)hydroxylamine 
• 64-17-5 ethanol 
• 57597-99-6 2,3-Dimethyl-4-phenylazo-phenol 
• 19499-93-5 2,3-dimethyl-4-nitrophenol 
• 526-75-0 2,3-Dimethylphenol 
• 74783-54-3 1-hydroxy-2,3-dimethyl-4-nitrosobenzene 
• 78660-13-6 p-(2,3-dimethyl-4-hydroxyphenylazo)benzenesulphonic acid 
• 83-41-0 2,3-dimethylnitrobenzene 
• 305-80-6 4-diazobenzenesulfonic acid 

Downstream Products

• 526-86-3 2,3-dimethyl-1,4-benzoquinone 
• 35355-33-0 2,3-Dimethylhydroquinone monomethyl ether 
• 2011-57-6 N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide 
• 74783-55-4 4-acetamino-1-methoxy-2,3-dimethylbenzene 
• 114747-32-9 N-(4-methoxy-2,3-dimethylphenyl)aniline 
• 1174550-01-6 1-(4-hydroxy-2,3-dimethylphenyl)-3-phenylurea 
• 224450-47-9 (4-hydroxy-2,3-dimethylphenyl)carbamic acid tert-butyl ester 
• 1616410-88-8 N-(4-hydroxy-2,3-dimethylphenyl)-N′-(4-chlorophenylsulfonyl)acetamidine 
• 1616410-88-8 N-(4-hydroxy-2,3-dimethylphenyl)-N′-(4-chlorophenylsulfonyl)acetamidine 
• 1413925-86-6 N-(2,3-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)-3-phenylprop-2-enamide 
• 1413925-71-9 (2E)-N-(4-hydroxy-2,3-dimethylphenyl)-3-phenylprop-2-enamide 
• 1413925-81-1 N-(2,3-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)phenoxyacetamide 
• 1413925-63-9 N-(4-hydroxy-2,3-dimethylphenyl)-2-phenoxyacetamide 
• 1413925-76-4 N-(2,3-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methylphenylacetamide 

Relevant articles and documents

Novel potent BRAF inhibitors: Toward 1 nM compounds through optimization of the central phenyl ring

BRAF, a serine/threonine specific protein kinase that is part of the MAPK pathway and acts as a downstream effector of RAS, is a potential therapeutic target in melanoma. We have developed a series of small-molecule BRAF inhibitors based on a 1H-imidazo[4,5-b]pyridine-2(3H)-one scaffold (ring A) as the hinge binding moiety and a number of substituted phenyl rings C that interact with the allosteric binding site. The introduction of various groups on the central phenyl ring B combined with appropriate A- and C-ring modifications afford very potent compounds that inhibit V600EBRAF kinase activity in vitro and oncogenic BRAF signaling in melanoma cells. Substitution on the central phenyl ring of a 3-fluoro, a naphthyl, or a 3-thiomethyl group improves activity to yield compounds with an IC50 of 1 nM for purified V 600EBRAF and nanomolar activity in cells.

IMIDAZO[4,5-B]PYRIDIN-2-ONE AND OXAZOLO[4,5-B]PYRIDIN-2-ONE COMPOUNDS AND ANALOGS THEREOF AS THERAPEUTIC COMPOUNDS

The present invention pertains to certain imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., and more particularly to compounds of the formula (I): wherein: J is independently -O- or -NRN1-; RN1, if present, is independently -H or a substituent; RN2 is independently -H or a substituent; Y is independently -CH= or -N=; Q is independently -(CH2)j-M-(CH2)k- wherein: j is independently 0, 1 or 2; k is independently 0, 1, or 2; j+k is 0, 1, or 2; M is independently -O-, -S-, -NH-, -NMe-, or -CH2-; each of RP1, RP2, RP3, and RP4 is independently -H or a substituent; and additionally RP1 and RP2 taken together may be -CH=CH-CH=CH-; L is independently: a linker group formed by a chain of 2, 3, or 4 linker moieties; each linker moiety is independently -CH2-,-NRN-, -C(=X)-, or -S(=O)2-; exactly one linker moiety is -NRN-, or: exactly two linker moieties are -NRN-; exactly one linker moiety is -C(=X)-, and no linker moiety is -S(=O)2-; or: exactly one linker moiety is -S(=O)2-, and no linker moiety is -C(=X)-; no two adjacent linker moieties are -NRN-; X is independently =O or =S; each RN is independently -H or a substituent; A is independently: C6-14carboaryl, C5-14heteroaryl, C3-12carbocyclic, C3-12heterocyclic; and is independently unsubstituted or substituted; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, N-oxides, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., B-RAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, to inhibit cell proliferation, and in the treatment of diseases and conditions that are ameliorated by the inhibition of RAF, RTK, etc., proliferative conditions such as cancer (e.g., colorectal cancer, melanoma), etc.

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.

Hair colouring and conditioning compositions

A hair colouring and conditioning composition comprising: (a) a hair colouring agent; and (b) a hair conditioning agent; wherein the composition provides an Average Combing Index Value of greater than 1.2 as measured by the Combing Technical Test Method. The products can provide excellent hair colouring together with excellent conditioning, reduced hair damage, brittleness and dryness, and is convenient and easy to use.

Hair conditioning compositions and their use in hair colouring compositions

The present invention relates to a hair care composition comprising a aminofunctional polysiloxane having a specified average effective particle size which provides improved durable conditioning particularly when utilised in conjunction with a hair colouring composition.

Enhanced color deposition for hair with sequestering agents

Hair coloring compositions which comprise: (A) non-nitrogenous chelating agents from the group consisting of polyphosphate; phosphonates; hydroxycarboxylates; polyacrylates; zeolite; and mixtures thereof; (B) an oxidative dye primary intermediate; and (C) an oxidative dye coupler; (D) and water are described. The present invention also relates to a method for coloring hair which comprises contacting said hair with a hair coloring composition as described above.

Transition metal complexes as dye forming catalysts in hair coloring compositions

A hair coloring composition comprising a first composition which comprises: (a) a dye forming transition metal salt or complex; which is first applied to the hair; and a second composition which comprises the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an aminophenol, a polyhydric phenol a catechol and mixtures thereof.

HAIR COLORING COMPOSITIONS

A hair coloring composition comprising: (a) from about 0.0003 moles (per 100 g of composition) to less than about 0.09 moles (per 100 g of composition) of an inorganic peroxygen oxidizing agent; and (b) an oxidative hair coloring agent; wherein the pH of each of (a) and (b) is in the range of from about 1 to about 6 and wherein the combined mixture of (a) and (b) has a pH in the range of from about 1 to about 6. The products can provide excellent hair coloring and in-use efficacy benefits including excellent initial color and good wash fastness in combination with reduced hair damage at low pH.

HAIR COLORING COMPOSITIONS

A hair coloring composition comprising: (a) a preformed organic peroxyacid oxidising agent; and (b) an oxidative hair coloring agent; wherein the pH of each of components (a) and (b) is in the range of from about pH 1 to less than about pH 7 and wherein the pH of the composition is in the range of from about pH 1 to less than about pH 7. The products can provide excellent hair coloring and in-use efficacy benefits including excellent initial color and good wash fastness in combination with reduced hair damage at low pH.

Synthesis of 4-deoxycarbazomycin B: A convenient alternative

4-Deoxycarbazomycin B(3) was synthesized by condensation of 4-methoxy-2,3-dimethylacetanilide (8) with bromobenzene in presence of cuprous iodide and potassium carbonate, and subsequent hydrolysis with 20% aqueous ethanolic KOH, followed by cyclisation of the resulting substituted diphenylamine (9) with palladium acetate in acetic acid.