2011-57-6

Basic information

• Product Name: N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide
• Synonyms: N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide
• CAS NO: 2011-57-6
• Molecular Weight: 179.219
• Mol File: 2011-57-6.mol

Chemical Properties

• CAS DataBase Reference: N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide(2011-57-6)
• EPA Substance Registry System: N-(4-hydroxy-2,3-dimethyl-phenyl)acetamide(2011-57-6)

Safety Data

• Hazardous Substances Data: 2011-57-6(Hazardous Substances Data)

Upstream product

• 74783-54-3 1-hydroxy-2,3-dimethyl-4-nitrosobenzene 
• 108-24-7 acetic anhydride 
• 526-75-0 2,3-Dimethylphenol 
• 121-57-3 4-aminobenzene sulfonic acid 
• 94276-04-7 4-amino-2,3-dimethyl-1-hydroxybenzene hydrochloride 
• 3096-69-3 4-amino-2,3-dimethylphenol 
• 684201-97-6 4-Sulfobenzolazo-acetoacetaldehyd 
• 78-93-3 butanone 
• 153782-51-5 4-(t-butyldimethylsilyloxy)-2,3-dimethylacetanilide 

Downstream Products

• 142902-33-8 4-Acetylamino-2,3-dimethyl-6-(2-methyl-2-propenyl)phenol 
• 179067-16-4 4-methoxy-2,3-dimethylaniline hydrochloride 
• 114747-32-9 N-(4-methoxy-2,3-dimethylphenyl)aniline 
• 74783-55-4 4-acetamino-1-methoxy-2,3-dimethylbenzene 
• 142874-37-1 4-Acetylamino-2,3-dimethyl-1-(2-methyl-2-propenyloxy)benzene 

Relevant articles and documents

Synthesis of 4-deoxycarbazomycin B: A convenient alternative

4-Deoxycarbazomycin B(3) was synthesized by condensation of 4-methoxy-2,3-dimethylacetanilide (8) with bromobenzene in presence of cuprous iodide and potassium carbonate, and subsequent hydrolysis with 20% aqueous ethanolic KOH, followed by cyclisation of the resulting substituted diphenylamine (9) with palladium acetate in acetic acid.

A new synthesis of 4-deoxycarbazomycin B and its antimicrobial properties

A new synthesis 4-deoxycarbazomycin B (3) has ben achieved using Japp-Klingemann reaction for the preparation of the required hydrazone 12 starting from the amine hydrochloride 9 and 2-hydroxymethylenecyclohexanone 11. The hydrazone 12 on indolisation with cone. HCl and AcOH furnishes the keto-tetrahydrocarbazole 13 which on Wolff-Kishner reduction followed by dehydrogenation with Pd/C affords 3. A new method for the synthesis of the starting amine hydrochloride 9 has been developed. Compound 3 shows significant inhibitory activity against various gram-positive and gram-negative bacteria.

Aminocoumaran derivatives, their production and use

A novel aminocoumaran derivatives of the general formula (I): STR1 wherein R1 and R2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R3 R4 and R5 are an optionally acylated hydroxyl optionally substituted amino group, alkoxy group or aliphatic group, or two of R3, R4 and R5 may be linked together to form a carbocyclic group; R6 and R7 are an aliphatic group and at least one of them has a methylene group at the α-position; R8 and R9 are a hydrogen atom or an aliphatic group or aromatic group, or a salt thereof is useful for medicines for preventing and treating various diseases such as arterial schleosis, hepatopathy, cerebrovascular diseases and the like.

The Fischer indolisation reaction and the synthesis of dihydroindenoindoles

The Fischer reaction between indanones and certain alkoxyarylhydrazines fails; the indanones are returned unreacted and the arylhydrazines are converted into the corresponding alkoxy-2-chloroarylamines and other products.A new N-amination route to arylhydrazines from the arylamines has been developed and it has been demonstrated that problems with the indolisation of alkoxyarylhydrazones can be circumvented by ring closures of their O-tosylated analogues.Some results using the Lepke synthesis of indoles are recorded.

Photochemical hydroxylation of 7,8-dimethylalloxazine (lumichrome). Structure elucidation of the irradiation product

The synthesis of 8-methoxy-3-(methoxycarbonyl)-6,7-dimethyl-2-(methylamino)quinoxaline is described.The synthesized compound appeared to be identical with the product obtained by degradation of the irradiation product of lumichrome.From this the conclusion is drawn that the irradiation product of lumichrome in water is 9-hydoxylumichrome.