114774-09-3Relevant academic research and scientific papers
A 2 - carboxamide - 5 - (2 - mercapto - 1, 3 - thiazole - 4 - yl) - thiophene preparation method
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Paragraph 0026; 0027, (2017/08/25)
The invention discloses a preparation method of 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The preparation method comprises the following steps: firstly synthetizing 2-(alpha-methoxyl group ammonia) ethylthiophene, then successively synthetizing 5-acetyl -2-(alpha-methoxyl group ammonia) ethylthiophene, 5-(alpha-methoxyl group ammonia) ethyl-2-thiophene carboxylic acid and a crude product of a 5-acetyl-2-thiophene carboxylic acid, after the crude product of the 5-acetyl-2-thiophene carboxylic acid is re-refined, then successively synthetizing 5-acetyl-2- thiophene acyl chloride, 5-acetyl-2-thiophene acidamide, 5-bromo acetyl -2-thiophene acidamide and 5-acidamide-2-thiophene acetyl thiocyanates, and finally synthetizing the product of the 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene prepared by the preparation method disclosed by the invention is good in quality and high in yield.
