52560-89-1

Usage

Uses

Used in Pharmaceutical Industry:
5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide is used as a key intermediate in the multi-step synthesis of arotinolol hydrochloride, a medication used to treat high blood pressure and angina pectoris. Its role in the synthesis process is crucial for the production of the final drug product, highlighting its importance in the pharmaceutical sector.
Note: Since the provided materials only mention the use of 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide in the synthesis of arotinolol hydrochloride, no other applications or industries are listed. If there are additional uses or industries not mentioned in the provided materials, they would need to be researched and added separately.

InChI:InChI=1/C8H6N2OS3/c9-7(11)6-2-1-5(14-6)4-3-13-8(12)10-4/h1-3H,(H2,9,11)(H,10,12)

Upstream product

• 88-15-3 2-Acetylthiophene 
• 114773-97-6 2-(α-methoxyimino)ethylthiophene 
• 114774-08-2 5-acetyl-2-(α-methoxyimino)ethylthiophene 
• 114774-09-3 5-(α-methoxyimino)ethyl-2-thiophenecarboxylic acid 
• 4066-41-5 5-acetylthiophene-2-carboxylic acid 
• 89692-69-3 5-acetyl-thiophene-2-carbonyl chloride 
• 68257-89-6 5-acetylthiophene-2-carboxamide 
• 68257-90-9 5-(2-bromoacetyl)thiophene-2-carboxamide 
• 4101-81-9 methyl 5-acetyl-2-thiophenecarboxylate 

Downstream Products

• 101540-26-5 arotinolol hydrochloride 
• 68377-92-4 arotinolol 

Relevant academic research and scientific papers

Preparation method of arotinolol hydrochloride

The invention provides a preparation method of arotinolol hydrochloride, which comprises the following steps of: reacting a compound shown as a structural formula VIII with absolute methanol in the presence of concentrated sulfuric acid to obtain a compou

A 2 - carboxamide - 5 - (2 - mercapto - 1, 3 - thiazole - 4 - yl) - thiophene preparation method

The invention discloses a preparation method of 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The preparation method comprises the following steps: firstly synthetizing 2-(alpha-methoxyl group ammonia) ethylthiophene, then successively synthetizing 5-acetyl -2-(alpha-methoxyl group ammonia) ethylthiophene, 5-(alpha-methoxyl group ammonia) ethyl-2-thiophene carboxylic acid and a crude product of a 5-acetyl-2-thiophene carboxylic acid, after the crude product of the 5-acetyl-2-thiophene carboxylic acid is re-refined, then successively synthetizing 5-acetyl-2- thiophene acyl chloride, 5-acetyl-2-thiophene acidamide, 5-bromo acetyl -2-thiophene acidamide and 5-acidamide-2-thiophene acetyl thiocyanates, and finally synthetizing the product of the 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene prepared by the preparation method disclosed by the invention is good in quality and high in yield.