52560-89-1

Basic information

• Product Name: 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide
• Synonyms: 5-(2,3-Dihydro-2-thioxo-4-thiazolyl)-2-thiophenecarboxamide;NSC 317939;Arotinolol hydrochloride interMediate product;5-(2-Mercapto-thiazol-4-yl)-thiophene-2-carboxylic acid aMide;5-(2-Thioxo-2,3-dihydrothiazol-4-yl)thiophene-2-carboxaMide;5-(2-Sulfanyl-1,3-thiazol-4-yl)thiophene-2-carboxamide;5-(2-Thioxo-2,3-dihydrothiazol-4-yl);5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide
• CAS NO: 52560-89-1
• Molecular Formula: C8H6N2OS3
• Molecular Weight: 242.34
• Mol File: 52560-89-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 471.1°C at 760 mmHg
• Flash Point: 238.7 °C
• Appearance: /
• Density: 1.63
• Vapor Pressure: 4.8E-09mmHg at 25°C
• Refractive Index: 1.806
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 7.23±0.40(Predicted)
• CAS DataBase Reference: 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide(52560-89-1)
• EPA Substance Registry System: 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide(52560-89-1)

Safety Data

• Hazardous Substances Data: 52560-89-1(Hazardous Substances Data)

Usage

Uses

5-(2-Sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide is a compound involved in the multi-step synthesis of arotinolol hydrochloride.

InChI:InChI=1/C8H6N2OS3/c9-7(11)6-2-1-5(14-6)4-3-13-8(12)10-4/h1-3H,(H2,9,11)(H,10,12)

Upstream product

• 4101-81-9 methyl 5-acetyl-2-thiophenecarboxylate 
• 68257-90-9 5-(2-bromoacetyl)thiophene-2-carboxamide 
• 68257-89-6 5-acetylthiophene-2-carboxamide 
• 89692-69-3 5-acetyl-thiophene-2-carbonyl chloride 
• 4066-41-5 5-acetylthiophene-2-carboxylic acid 
• 114774-09-3 5-(α-methoxyimino)ethyl-2-thiophenecarboxylic acid 
• 114774-08-2 5-acetyl-2-(α-methoxyimino)ethylthiophene 
• 114773-97-6 2-(α-methoxyimino)ethylthiophene 
• 88-15-3 2-Acetylthiophene 

Downstream Products

• 101540-26-5 arotinolol hydrochloride 
• 68377-92-4 arotinolol 

Relevant articles and documents

Preparation method of arotinolol hydrochloride

The invention provides a preparation method of arotinolol hydrochloride, which comprises the following steps of: reacting a compound shown as a structural formula VIII with absolute methanol in the presence of concentrated sulfuric acid to obtain a compou