68257-89-6

Basic information

• Product Name: 5-ACETYLTHIOPHENE-2-CARBOXAMIDE
• Synonyms: 5-ACETYLTHIOPHENE-2-CARBOXAMIDE;2-THIOPHENECARBOXAMIDE, 5-ACETYL
• CAS NO: 68257-89-6
• Molecular Formula: C7H7NO2S
• Molecular Weight: 169.20098
• Mol File: 68257-89-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 359.3 °C at 760 mmHg
• Flash Point: 171.1 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 2.4E-05mmHg at 25°C
• Refractive Index: 1.59
• PKA: 15.21±0.50(Predicted)
• CAS DataBase Reference: 5-ACETYLTHIOPHENE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ACETYLTHIOPHENE-2-CARBOXAMIDE(68257-89-6)
• EPA Substance Registry System: 5-ACETYLTHIOPHENE-2-CARBOXAMIDE(68257-89-6)

Safety Data

• Hazardous Substances Data: 68257-89-6(Hazardous Substances Data)

Usage

Uses

5-Acetylthiophene-2-carboxamide acts as a reagent for the synthesis and β- adrenergic blocking action of a new thiazolythiopropanolamine.

InChI:InChI=1/C7H7NO2S/c1-4(9)5-2-3-6(11-5)7(8)10/h2-3H,1H3,(H2,8,10)

Upstream product

• 88-15-3 2-Acetylthiophene 
• 114773-97-6 2-(α-methoxyimino)ethylthiophene 
• 114774-08-2 5-acetyl-2-(α-methoxyimino)ethylthiophene 
• 114774-09-3 5-(α-methoxyimino)ethyl-2-thiophenecarboxylic acid 
• 89692-69-3 5-acetyl-thiophene-2-carbonyl chloride 
• 4101-81-9 methyl 5-acetyl-2-thiophenecarboxylate 
• 4066-41-5 5-acetylthiophene-2-carboxylic acid 

Downstream Products

• 52560-89-1 5-(2-mercapto-1,3-thiazol-4-yl)-2-thiophene carboxamide 
• 101540-26-5 arotinolol hydrochloride 
• 68257-90-9 5-(2-bromoacetyl)thiophene-2-carboxamide 

Relevant articles and documents

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A 2 - carboxamide - 5 - (2 - mercapto - 1, 3 - thiazole - 4 - yl) - thiophene preparation method

The invention discloses a preparation method of 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The preparation method comprises the following steps: firstly synthetizing 2-(alpha-methoxyl group ammonia) ethylthiophene, then successively synthetizing 5-acetyl -2-(alpha-methoxyl group ammonia) ethylthiophene, 5-(alpha-methoxyl group ammonia) ethyl-2-thiophene carboxylic acid and a crude product of a 5-acetyl-2-thiophene carboxylic acid, after the crude product of the 5-acetyl-2-thiophene carboxylic acid is re-refined, then successively synthetizing 5-acetyl-2- thiophene acyl chloride, 5-acetyl-2-thiophene acidamide, 5-bromo acetyl -2-thiophene acidamide and 5-acidamide-2-thiophene acetyl thiocyanates, and finally synthetizing the product of the 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene. The 2-formylamine-5-(2-sulfhydryl-1, 3-thiazole-4-base)-thiophene prepared by the preparation method disclosed by the invention is good in quality and high in yield.