1148000-93-4Relevant articles and documents
Phosphine-catalyzed stereoselective dimerizations of ketenes
Ibrahim, Ahmad A.,Wei, Pei-Hsun,Harzmann, Gero D.,Nalla, Divya,Mondal, Mukulesh,Wheeler, Kraig A.,Kerrigan, Nessan J.
, (2020/12/21)
Full details of optimisation studies of the phosphine-catalyzed ketene homodimerization reaction and the detailed development of an asymmetric variant are discussed. Studies towards the development of a phosphine-catalyzed ketene heterodimerization reaction are revealed. A discussion of possible reaction mechanisms for the dimerization reactions, supported by spectroscopic analysis of intermediates and trapping experiments, is also presented.
Josiphos-catalyzed asymmetric homodimerization of ketoketenes
Ibrahim, Ahmad A.,Wei, Pei-Hsun,Harzmann, Gero D.,Kerrigan, Nessan J.
scheme or table, p. 7901 - 7904 (2011/03/19)
In this paper the development of a chiral phosphine-catalyzed homodimerization of ketoketenes that provides access to a variety of highly substituted ketoketene dimer β-lactones (11 examples) is reported. The Josiphos catalytic system displays good to exc
Asymmetric dimerization of disubstituted ketenes catalyzed by N-heterocyclic carbenes
Lv, Hui,Zhang, Yan-Rong,Huang, Xue-Liang,Ye, Song
supporting information; experimental part, p. 2715 - 2718 (2009/10/20)
A series of chiral N-heterocyclic carbenes (NHCs), derived from L-pyrogutamic acid, were found to be efficient catalysts for the asymmetric dimerization of alkylarylketenes to give the corresponding α-quaternary β-alkylidenyl-β-lactones in good yields with up to 97% ee. A chiral NHC with a proximal hydroxy group is superior in comparison with the corresponding NHC with its hydroxy group protected.
