1148008-69-8Relevant articles and documents
Concise SAR Exploration Based on the "head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds
Noji, Satoru,Seki, Noriyoshi,Maeba, Takaki,Sakai, Takayuki,Watanabe, Eiichi,Maeda, Katsuya,Fukushima, Kyoko,Noguchi, Toru,Ogawa, Kazuya,Toyonaga, Yukiyo,Negoro, Tamotsu,Kawasaki, Hisashi,Shiozaki, Makoto
, p. 919 - 923 (2016)
In typical kinase inhibitor programs, a hinge binder showing best potency with preferential specificity is initially selected, followed by fine-tuning of the accompanying substituents on its core module. A shortcoming of this approach is that the exclusiv
