1148008-69-8Relevant articles and documents
Concise SAR Exploration Based on the "head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds
Noji, Satoru,Seki, Noriyoshi,Maeba, Takaki,Sakai, Takayuki,Watanabe, Eiichi,Maeda, Katsuya,Fukushima, Kyoko,Noguchi, Toru,Ogawa, Kazuya,Toyonaga, Yukiyo,Negoro, Tamotsu,Kawasaki, Hisashi,Shiozaki, Makoto
, p. 919 - 923 (2016)
In typical kinase inhibitor programs, a hinge binder showing best potency with preferential specificity is initially selected, followed by fine-tuning of the accompanying substituents on its core module. A shortcoming of this approach is that the exclusiv
PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS
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Page/Page column 81-82, (2009/05/30)
Invented is a method of inhibiting the activity/function of PB kinases using pyridosulfonamide derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridosulfonamide derivatives.