1148155-01-4

Upstream product

• 1148155-00-3 tert-butyl [4,7-bis-tert-butoxycarbonylmethyl-10-(4-nitrobenzoyl)-1,4,7,10-tetraazacyclododec-1-yl]acetate 
• 122-04-3 4-nitro-benzoyl chloride 
• 122555-91-3 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane 

Relevant academic research and scientific papers

Reductive Amination-A convenient method for generating diverse, mono-functionalised 5,10,15,20-tetraphenyl porphyrins

Formylation followed by reductive amination of 5,10,15,20-tetraphenyl porphyrin (TPP) is shown to be a versatile synthetic procedure for monosubstitution of the porphyrin core re-giospecifically at one β-position. A diverse range of substituents can be introduced in this way in good yields, including cyclen aza-crown macrocycles. Georg Thieme Verlag Stuttgart.

Design and synthesis of two new terbium and europium complex-based luminescent probes for the selective detection of zinc ions

Zinc plays a key role in many physiological processes and has implications for the environment. Consequently, detection of chelatable zinc ion (Zn2+) has attracted widespread interest from the research community. Lanthanide-based luminescent probes offer particular advantages, such as high water solubility, long luminescence lifetimes and a large Stokes’ shift, over common organic dye-based fluorescent sensors. Here, we report the synthesis of terbium and europium complex-based probes, Tb-1 and Eu-1, for sensitive and selective detection of Zn2+ in water. These probes featured the incorporation of bis(2-pyridylmethyl)]amine (DPA) receptor for Zn2+ chelation and the 1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DO3A) ring to chelate lanthanide (Ln3+). Tb-1 and Eu-1 displayed high selectivity for Zn2+ ions over a wide range of competing ions, with limits of detection of 0.50 ± 0.1 μM and 1.5 ± 0.01 μM, respectively. Density functional theory simulations were in good agreement with experimental observations, displaying high Zn2+ selectivity compared with most competing ions. In the competing ions experiments, the luminescence response of Tb-1 and Eu-1 was moderately quenched by some ions such as Cu2+, this was linked to the comparable binding abilities of these ions for the receptor of the probe.