114828-09-0Relevant articles and documents
Synthesis of myo-Inositol 1,3,4,5-Tetraphosphate and myo-Inositol 1,3-Biphosphate
Billington, David C.,Baker, Raymond
, p. 1011 - 1013 (1987)
myo-Inositol 1,3,4,5-tetraphosphate, myo-inositol 3,4-biphosphate, and myo-inositol 4-phosphate have been prepared via routes in which a key step is a novel, highly regioselective monooalkylation of myo-inositol orthoformate.
The Total Synthesis of myo-Inositol Phosphates via myo-Inositol Orthoformate
Billington, David C.,Baker, Raymond,Kulagowski, Janusz J.,Mawer, Ian M.,Vacca, Joseph P.,et al.
, p. 1423 - 1429 (2007/10/02)
Novel selective alkylations of myo-inositol orthoformate (4) have been used to prepare a series of protected myo-inositol derivatives, (5a-e), (7), (10), (12), and (16).These intermediates have been used in efficient total syntheses of myo-inositol 2-phosphate, (9); myo-inositol 4-phosphate, (6); myo-inositol 1,3-bisphosphate, (18); and myo-inositol 1,3,4,5-tetrakisphosphate (14).This report represents the first total synthesis of the important natural metabolites (14) and (18) and significantly improved methods of preparation of (6) and (9).