114896-50-3Relevant articles and documents
A novel access to tetrahydro-β-carbolines via one-pot hydroformylation/fischer indole synthesis: Rearrangement of 3,3- spiroindoleninium cations
Bondzic, Bojan P.,Eilbracht, Peter
supporting information; experimental part, p. 3433 - 3436 (2009/05/07)
(Chemical Equation Presented) The two component one-pot hydroformylation/Fischer indole synthesis sequence of 2,5 dihydropyrroles and phenyl hydrazines allows a facile and convenient access to tetrahydro-β- carbolines in moderate to good yields.
1-METHYL-, 1-PHENYL, AND 1-(2-(2-DIMETHYLAMINOETHOXY)PHENYL)-2,3,4,9-TETRAHYDRO-1H-PYRIDOINDOLE AND THEIR 2-SUBSTITUTED DERIVATIVES: SYNTHESIS AND PHARMACOLOGICAL SCREENING
Hulinska, Hana,Taufmann, Petr,Frycova, Hana,Protiva, Miroslav
, p. 373 - 380 (2007/10/02)
1-Methyl- and 1-phenyl-2,3,4,9-tetrahydro-1H-pyridoindole (I and IV) were transformed via the chloroacetyl derivatives II and V to the 4-methylpiperazinoacetyl compounds III and VI; compound VI inhibits effectively the formation of the indomethacin-induced gastric ulcers in rats but is devoid of anticholinergic activity and does not inhibit the gastric secretion in rats.Reaction of tryptamine with 2-(2-dimethylaminoethoxy)benzaldehyde afforded compound IX which proved inactive in tests for antidepressant activity.Compounds IV and IX were treated with ethyl chloroformate and gave carbamates VII and X; compound VII does not show anticonvulsant activity.