114902-16-8

Basic information

• Product Name: yemuoside YM(10)
• Synonyms: yemuoside YM(10);CIWUJIANOSIDE B (RG);acanthopanax senticosides B;Ciwujianoside B, 98%, from Acanthopanax senticosus (Rupr. & Maxim.) Harms
• CAS NO: 114902-16-8
• Molecular Formula: C₅₈H₉₂O₂₅
• Molecular Weight: 1187.37
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Triterpenoids
• Mol File: 114902-16-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.48
• Refractive Index: 1.637
• PKA: 12.50±0.70(Predicted)
• CAS DataBase Reference: yemuoside YM(10)(CAS DataBase Reference)
• NIST Chemistry Reference: yemuoside YM(10)(114902-16-8)
• EPA Substance Registry System: yemuoside YM(10)(114902-16-8)

Safety Data

• Hazardous Substances Data: 114902-16-8(Hazardous Substances Data)

Usage

General Description

Yemuoside YM(10) is a novel triterpenoid saponin compound isolated from the Chinese medicinal herb Gleditsia sinensis Lam. It has been reported to possess various pharmacological activities, including anti-inflammatory, anti-tumor, and anti-fibrotic effects. In in vitro studies, yemuoside YM(10) has been shown to inhibit the production of pro-inflammatory cytokines and reduce the proliferation of cancer cells. It also exhibits anti-fibrotic properties by suppressing the activation of fibroblasts and the deposition of extracellular matrix proteins. Additionally, yemuoside YM(10) has shown potential as a therapeutic agent for the treatment of liver fibrosis, lung fibrosis, and other fibrotic disorders. Its diverse pharmacological activities make it a promising candidate for further research and development as a pharmaceutical compound.

InChI:InChI=1/C58H92O25/c1-23-11-16-58(53(73)83-51-44(71)40(67)37(64)30(79-51)22-75-48-45(72)41(68)46(29(20-59)78-48)81-49-42(69)38(65)34(61)24(2)76-49)18-17-56(7)26(27(58)19-23)9-10-32-55(6)14-13-33(54(4,5)31(55)12-15-57(32,56)8)80-52-47(36(63)28(60)21-74-52)82-50-43(70)39(66)35(62)25(3)77-50/h9,24-25,27-52,59-72H,1,10-22H2,2-8H3/t24-,25-,27-,28-,29+,30+,31-,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56+,57+,58-/m0/s1

Upstream product

• 114892-56-7 ciwujianoside C₂ 

Downstream Products

• 5328-37-0 L-arabinose 
• 3615-41-6 L-Rhamnose 
• 50-99-7 D-glucose 

Relevant articles and documents

Saponins from Leaves of Acanthopanax senticosus HARMS., Ciwujia; Structures of Ciwujianosides B, C1, C2, C3, C4, D1, D2 and E

Eleven triterpenoid saponins were isolated from the leaves of a Chinese folk medicine, Acanthopanax senticosus (RUPR. et MAXIM) HARMS.Of these compounds, three were identified as known saponins.The structures of eight new saponins named ciwujianosides B (1), C1, (2), C2 (3), C3 (4), C4 (5), D1 (6), D2 (7), and E (8) were elucidated to be as follows: (1), 3-O-α-rhamnopyranosyl-(1->2)-β-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (2), 3-O-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (3), 3-O-α-rhamnopyranosyl-(1->2)-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (4), 3-O-α-arabinopyranosyl oleanolic acid 28-O-α-rhamnopyranosyl-(1->4)-β-glucopyranosyl(1->6)-β-glucopyranosyl ester; (5), 3-O-α-rhamnopyranosyl-(1->2)-α-arabinopyranosyl oleanolic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (6), 3-O-α-arabinopyranosyl oleanolic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl(1->6)-β-glucopyranosyl ester; (7), 3-O-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-b-glucopyranosyl-30-norolean-12,20(29)-dien-28-oic acid 28-O-α-rhamnopyranosyl-(1->4)-6-O-acetyl-β-glucopyranosyl-(1->6)-β-glucopyranosyl ester; (8), 3-O-α-rhamnopyranosyl-(1->2)-α-arabinopyranosyl-30-norolean-12,20(29)-dien-28-oic acid.Keywords - Acanthopanax senticosus; Araliaceae; saponin; Chinese folk medicine; ciwujianoside; oleanolic acid glycoside; noroleanolic acid glycoside; 30-norolean-12,20(29)-dien-28-oic acid; ciwujia