1149372-03-1

Basic information

• Product Name: C₂₉H₄₂N₂O₂
• Synonyms: C₂₉H₄₂N₂O₂
• CAS NO: 1149372-03-1
• Molecular Weight: 450.665
• Mol File: 1149372-03-1.mol

Chemical Properties

• CAS DataBase Reference: C₂₉H₄₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₄₂N₂O₂(1149372-03-1)
• EPA Substance Registry System: C₂₉H₄₂N₂O₂(1149372-03-1)

Safety Data

• Hazardous Substances Data: 1149372-03-1(Hazardous Substances Data)

Upstream product

• 1149371-93-6 ethyl (5β,8α,9β,10α,13α)-8-ethenyl-13-formyl-13-methylpodocarpan-15-oate 
• 59-88-1 phenylhydrazine hydrochloride 
• 1149371-92-5 ethyl (15β,16α)-16-hydroxy-15-({[(4-methylphenyl)sulfonyl]oxy}methyl)beyeran-18-oate 
• 160283-49-8 ethyl (4R,4aS,6aR,9S,11aR,11bS)-4,9,11b-trimethyl-8-oxotetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate 
• 27975-19-5 isosteviol 
• 57817-89-7 stevioside 
• 882175-41-9 ethyl (15β,16α)-16-hydroxy-15-(hydroxymethyl)beyeran-18-oate 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1149372-04-2 ethyl (3S,6bS,8aS,9R,12aS,12bS)-1,3,5,7,8,8a,9,10,11,12,12a,12b-dodecahydro-3,9,12a-trimethyl-5-phenyl-2H-3,6b-methanonaphtho[2',1': 3,4]cyclohepta[1,2-c]pyrazole-9-carboxylate 
• 1448582-50-0 C₂₉H₄₀N₂O₂ 

Relevant articles and documents

Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents

Two series of novel isosteviol-fused pyrazoline and pyrazole derivatives were facilely synthesized via intramolecular 1,3-dipolar cycloaddition and condensation reaction, respectively. All compounds were characterized by NMR, IR and HRMS spectra. The stereochemistry of compounds 9b, 10, 11a and 11v were further confirmed by X-ray crystallographic analysis. The antiproliferative activities of the structurally related pyrazoline and pyrazole derivatives were tested in vitro on four human malignant cell lines (SGC 7901, A549, Raji and HeLa): Our results revealed that isosteviol-fused pyrazole derivatives exhibited noteworthy cytotoxic activities. Among them, 2,4-di-Cl-phenylpyrazole derivative 11t displayed better cytotoxities with IC50 values: 2.71, 3.18, 1.09 and 13.52 mM against SGC 7901, A549, Raji and HeLa, respectively, compared to cisplatin (IC50 values: 7.56, 17.78, 17.32 and 14.31 μM, respectively).

Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities

By means of functional interconversions in ring D of the tetracyclic diterpene isosteviol (ent-16-ketobeyeran-19-oic acid 1), various 15- and 16-substituted isosteviol derivatives were stereoselectively prepared. The cytotoxic activities in vitro of these