114984-32-6

Basic information

• Product Name: diethyl 4-(phenylethynyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• Synonyms: diethyl 4-(phenylethynyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 114984-32-6
• Molecular Weight: 353.418
• Mol File: 114984-32-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl 4-(phenylethynyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 4-(phenylethynyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(114984-32-6)
• EPA Substance Registry System: diethyl 4-(phenylethynyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate(114984-32-6)

Safety Data

• Hazardous Substances Data: 114984-32-6(Hazardous Substances Data)

Upstream product

• 2579-22-8 Phenylpropargyl aldehyde 
• 626-34-6 ethyl aminocrotonate 
• 141-97-9 ethyl acetoacetate 

Relevant articles and documents

One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor

The Bohlmann-Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. In the Bohlmann-Rahtz reaction, the use of a Bronsted acid catalyst allows Michael addition and cyclodehydration to be carried out in a single step without isolation of intermediates to give the corresponding trisubstituted pyridine as a single regioisomer in good yield. Furthermore, 3-substituted propargyl aldehydes undergo Hantzsch dihydropyridine synthesis in preference to Bohlmann-Rahtz reaction in a very high yielding process that is readily transferred to continuous flow processing.