114992-39-1Relevant academic research and scientific papers
Synthesis of the proposed structure of queenslandon
Navickas, Vaidotas,Maier, Martin E.
supporting information; experimental part, p. 94 - 101 (2010/03/03)
The proposed structure of the benzolactone queenslandon (6) was synthesized utilizing a triol containing building block prepared from d-ribose. While a ring-closing metathesis approach did not lead to the macrocycle, alkylation of a benzyl(phenyl)selane, elimination to generate the styrene double bond, followed by Mitsunobu macrolactonization proved to be successful. Spectral data suggest that the structure of queenslandon should be revised, probably to the C11 epimer.
MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS
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Page/Page column 209-210, (2010/02/07)
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.
Syntheses of Karwinaphthol B, 7-Methoxyeleutherin and Ventiloquinone E.
Cameron, Donald W.,Crosby, Ian T.,Feutrill, Geoffrey I.,Pietersz, Goeffrey A.
, p. 2003 - 2024 (2007/10/02)
Acylation of the aryl nitromethane (35) with (9) gave the enone (45), which underwent cyclization to the tricyclic system (50).Thermally induced aromatization to the naphthopyran (51) and oxidation gave ventiloquinone E (3).On selective demethylation this
AN INVESTIGATION OF THE BIOSYNTHESIS OF CITROMYCETIN IN PENICILLIUM FREQUENTANS USING (13)C- AND (14)C-LABELLED PRECURSORS
Evans, Geoffrey E.,Staunton, James
, p. 755 - 762 (2007/10/02)
Citromycetin (1) has been shown by (13)C n.m.r. to incorporate seven intact acetate units from -, -, and -acetates in accordance with a polyketide biosynthesis.The distribution of radioactivity following incorporation of malonate was consistent with the utilisation of two starter units.The following possible advanced precursors, labelled with (14)C, were not incorporated : 2,4-dihydroxy-6-methylbenzoic acid (14), 4,5,7-trihydroxyphthalide (16), and 4,7-dihydroxy-5-methylcoumarin (18).Two compounds, 2,4,5-trihydroxy-6-methylbenzoic acid (15) and triacetic acid lactone (17), were degraded to radiolabelled acetate prior to incorporation.
