114992-41-5

Upstream product

• 38790-14-6 1,2,5-trimethoxy-3-methylbenzene 
• 23030-39-9 1-bromo-2,3,5-trimethoxybenzene 
• 79786-37-1 2,4,5-trimethoxy-6-methylbenzoic acid 
• 114992-39-1 2-bromo-3-methyl-1,4,5-trimethoxybenzene 
• 114992-40-4 methyl 2,4,5-trimethoxy-6-methylbenzoate 

Relevant academic research and scientific papers

AN INVESTIGATION OF THE BIOSYNTHESIS OF CITROMYCETIN IN PENICILLIUM FREQUENTANS USING (13)C- AND (14)C-LABELLED PRECURSORS

Citromycetin (1) has been shown by (13)C n.m.r. to incorporate seven intact acetate units from -, -, and -acetates in accordance with a polyketide biosynthesis.The distribution of radioactivity following incorporation of malonate was consistent with the utilisation of two starter units.The following possible advanced precursors, labelled with (14)C, were not incorporated : 2,4-dihydroxy-6-methylbenzoic acid (14), 4,5,7-trihydroxyphthalide (16), and 4,7-dihydroxy-5-methylcoumarin (18).Two compounds, 2,4,5-trihydroxy-6-methylbenzoic acid (15) and triacetic acid lactone (17), were degraded to radiolabelled acetate prior to incorporation.