79786-37-1

Upstream product

• 23030-39-9 1-bromo-2,3,5-trimethoxybenzene 
• 38790-14-6 1,2,5-trimethoxy-3-methylbenzene 
• 65614-48-4 ethyl 2,5-dihydroxy-4-methoxy-6-methylbenzoate 
• 79786-36-0 ethyl 2,4,5-trimethoxy-6-methylbenzoate 
• 124-38-9 carbon dioxide 
• 114992-39-1 2-bromo-3-methyl-1,4,5-trimethoxybenzene 
• 60059-02-1 2-methyl-3,4,6-trimethoxybenzaldehyde 

Downstream Products

• 79786-35-9 2,4,5-tri-O-methylhiascic acid 
• 957206-88-1 C₁₆H₂₆O₅Si 
• 603041-18-5 3,6-dihydroxy-4-methoxy-2-methyl-benzoic acid 
• 114992-41-5 methyl 2-bromomethyl-3,4,6-trimethoxybenzoate 
• 27613-31-6 2,4,5-trihydroxy-6-methylbenzoic acid 
• 114992-40-4 methyl 2,4,5-trimethoxy-6-methylbenzoate 

Relevant academic research and scientific papers

Synthesis of the proposed structure of queenslandon

The proposed structure of the benzolactone queenslandon (6) was synthesized utilizing a triol containing building block prepared from d-ribose. While a ring-closing metathesis approach did not lead to the macrocycle, alkylation of a benzyl(phenyl)selane, elimination to generate the styrene double bond, followed by Mitsunobu macrolactonization proved to be successful. Spectral data suggest that the structure of queenslandon should be revised, probably to the C11 epimer.

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.

AN INVESTIGATION OF THE BIOSYNTHESIS OF CITROMYCETIN IN PENICILLIUM FREQUENTANS USING (13)C- AND (14)C-LABELLED PRECURSORS

Citromycetin (1) has been shown by (13)C n.m.r. to incorporate seven intact acetate units from -, -, and -acetates in accordance with a polyketide biosynthesis.The distribution of radioactivity following incorporation of malonate was consistent with the utilisation of two starter units.The following possible advanced precursors, labelled with (14)C, were not incorporated : 2,4-dihydroxy-6-methylbenzoic acid (14), 4,5,7-trihydroxyphthalide (16), and 4,7-dihydroxy-5-methylcoumarin (18).Two compounds, 2,4,5-trihydroxy-6-methylbenzoic acid (15) and triacetic acid lactone (17), were degraded to radiolabelled acetate prior to incorporation.

2,4-Di-O-methylgyrophoric Acid and 2,4,5-Tri-O-methylhiascic Acid. New Tridepsides from Parmelia damaziana

The new tridepsides 2,4-di-O-methylgyrophoric acid (8) and 2,4,5-tri-O-methylhiascic acid (5) in addition to the known metabolites atranorin (9), chooroatranorin (10), ursolic acid (11), 5-O-methylhiascic acid (4) and gyrophoric acid (7) have been isolate