114992-47-1Relevant academic research and scientific papers
Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones
Das, Jagattaran,Rao, C.V. Laxman,Sastry,Roshaiah,Sankar, P. Gowri,Khadeer, Abdul,Kumar, M. Sitaram,Mallik, Arundhuti,Selvakumar,Iqbal, Javed,Trehan, Sanjay
, p. 337 - 343 (2007/10/03)
Some novel oxazolidinone derivatives have been synthesized and tested for antibacterial activity. Compound 13 was found to be active against Gram-positive pathogens whereas compound 14 was less active. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. However, thioacetamide analogue of 13 produced a potent molecule similar to linezolid in vitro. Some novel oxazolidinone derivatives with benzotriazole as pendant have been synthesized and tested for antibacterial activity. Linearly attached benzotriazole derivative showed more potency compared to angular one in vitro. Out of E/Z-isomers of angularly attached derivatives E-isomer was found to be more potent than Z-isomer. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. Finally, thioacetamide analogue of linear compound gave a lead having activity similar to linezolid in vitro.
Oxazolidinone antibacterial agents
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, (2008/06/13)
Compounds of formula (I) or therapeutically acceptable salts thereof, are useful for treating bacterial infections. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
Antibacterials. Synthesis and Structure-Activity Studies of 3-Aryl-2-oxooxazolidines. 2. The "A" Group
Gregory, Walter A.,Brittelli, David R.,Wang, C.-L. J.,Kezar, Hollis S.,Carlson, Randall K.,et al.
, p. 2569 - 2578 (2007/10/02)
The synthesis and structure-activity relationship (SAR) studies of the effect of varying the "A" group in a series of 5-(acetamidomethyl)oxazolidinone antibacterials (2) are described.Compounds 2 were principally prepared either by the six-step synthesis
