957783-10-7

Basic information

• Product Name: (4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester
• Synonyms: (4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester
• CAS NO: 957783-10-7
• Molecular Weight: 257.289
• Mol File: 957783-10-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester(957783-10-7)
• EPA Substance Registry System: (4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester(957783-10-7)

Safety Data

• Hazardous Substances Data: 957783-10-7(Hazardous Substances Data)

Usage

General Description

(4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester is a chemical compound with the molecular formula C15H15NO3. It is commonly used as a reagent in organic synthesis and pharmaceutical research. (4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester is an ester derived from (4-Hydroxymethyl-phenyl)-carbamic acid and benzyl alcohol. It appears as a white to off-white crystalline powder and is sparingly soluble in water. It is also known by the trade name Bendiocarb and is used as an insecticide to control pests in agriculture and public health. Additionally, (4-Hydroxymethyl-phenyl)-carbamic acid benzyl ester has shown potential as a pharmaceutical intermediate in the development of new drugs.

Upstream product

• 71150-68-0 benzyl N-(4-formylphenyl)carbamate 
• 623-04-1 4-aminobenzenemethanol 
• 501-53-1 benzyl chloroformate 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 1414968-21-0 Methanesulfonic acid 4-benzyloxycarbonylamino-benzyl ester 
• 840501-01-1 N-{(S)-3-[4-((E)-2-Benzotriazol-2-yl-2-cyano-vinyl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 840501-00-0 N-{3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 
• 840500-99-4 5-azidomethyl-3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-oxazolidin-2-one 
• 840500-98-3 3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-5-hydroxymethyl-oxazolidin-2-one 
• 128821-65-8 (S)-N-<<3-<4-(hydroxymethyl)phenyl>-2-oxo-5-oxazolidinyl>methyl>acetamide 
• 114992-47-1 (S)-N-<<3-(4-formylphenyl)-2-oxo-5-oxazolidinyl>methyl>acetamide 
• 1414968-22-1 [1-(4-Benzyloxycarbonylamino-benzyl)-piperidin-4-yl]-carbamic acid tert-butyl ester 
• 1392490-92-4 [4-(4-Acryloylamino-piperidin-1-ylmethyl)-phenyl]carbamic acid benzyl ester 

Relevant articles and documents

Chemoselective continuous-flow hydrogenation of aldehydes catalyzed by platinum nanoparticles dispersed in an amphiphilic resin

A chemoselective continuous-flow hydrogenation of aldehydes catalyzed by a dispersion of platinum nanoparticles in an amphiphilic polymer (ARP-Pt) has been developed. Aromatic and aliphatic aldehydes bearing various reducible functional groups, such as keto, ester, or amide groups, readily underwent flow hydrogenation in aqueous solutions within 22 s in a continuous-flow system containing ARP-Pt to give the corresponding primary benzylic or aliphatic alcohols in ≤99% yield with excellent chemoselectivity. Moreover, the long-term continuous-flow hydrogenation of benzaldehyde for 8 days was realized, and the total turnover number of the catalyst reached 997. The flow hydrogenation system provides an efficient and practical method for the chemoselective hydrogenation of aldehydes bearing reducible functional groups.

Effects of positional and geometrical isomerism on the biological activity of some novel oxazolidinones

Some novel oxazolidinone derivatives have been synthesized and tested for antibacterial activity. Compound 13 was found to be active against Gram-positive pathogens whereas compound 14 was less active. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. However, thioacetamide analogue of 13 produced a potent molecule similar to linezolid in vitro. Some novel oxazolidinone derivatives with benzotriazole as pendant have been synthesized and tested for antibacterial activity. Linearly attached benzotriazole derivative showed more potency compared to angular one in vitro. Out of E/Z-isomers of angularly attached derivatives E-isomer was found to be more potent than Z-isomer. Either less active or inactive molecules were obtained, when benzotriazole was replaced with benzimidazole, benzthiazole, or benzoxazole. Finally, thioacetamide analogue of linear compound gave a lead having activity similar to linezolid in vitro.