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1150103-05-1

1,1-dimethylethyl 4-[{[(6-cyano-3-pyridinyl)amino]carbonyl}(phenyl)amino]-1-piperidinecarboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1150103-05-1 Structure

  • Basic information

    1. Product Name: 1,1-dimethylethyl 4-[{[(6-cyano-3-pyridinyl)amino]carbonyl}(phenyl)amino]-1-piperidinecarboxylate
    2. Synonyms: 1,1-dimethylethyl 4-[{[(6-cyano-3-pyridinyl)amino]carbonyl}(phenyl)amino]-1-piperidinecarboxylate
    3. CAS NO:1150103-05-1
    4. Molecular Formula:
    5. Molecular Weight: 421.499
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1150103-05-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1,1-dimethylethyl 4-[{[(6-cyano-3-pyridinyl)amino]carbonyl}(phenyl)amino]-1-piperidinecarboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1,1-dimethylethyl 4-[{[(6-cyano-3-pyridinyl)amino]carbonyl}(phenyl)amino]-1-piperidinecarboxylate(1150103-05-1)
    11. EPA Substance Registry System: 1,1-dimethylethyl 4-[{[(6-cyano-3-pyridinyl)amino]carbonyl}(phenyl)amino]-1-piperidinecarboxylate(1150103-05-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1150103-05-1(Hazardous Substances Data)

1150103-05-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1150103-05-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,0,1,0 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1150103-05:
(9*1)+(8*1)+(7*5)+(6*0)+(5*1)+(4*0)+(3*3)+(2*0)+(1*5)=71
71 % 10 = 1
So 1150103-05-1 is a valid CAS Registry Number.

1150103-05-1Relevant articles and documents

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats

Duan, Maosheng,Kazmierski, Wieslaw M.,Chong, Pek Y.,DeAnda, Felix,Edelstein, Mark,Ferris, Rob,Peckham, Jennifer,Wheelan, Pat,Xiong, Zhiping,Zhang, Huichang,Nishizawa, Rena,Takaoka, Yoshikazu

, p. 6470 - 6475 (2011/11/29)

A novel series of pyridyl carboxamide-based CCR5 inhibitors was designed, synthesized, and demonstrated to be highly potent against HIV-1 infection in both HOS and PBL assays. Attempts to evaluate this series of compounds in a rat PK model revealed its instability in rat plasma. A hypothesis for this liability was proposed, and strategies to overcome this issue were pursued, leading to discovery of highly potent 40 and 41, which featured dramatically improved rat PK profiles. 2011 Elsevier Ltd. All rights reserved.

CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS

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Page/Page column 16-17, (2009/06/27)

The present invention relates to compounds useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS

-

Page/Page column 20; 21, (2009/06/27)

The present invention relates to compounds useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

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