115012-57-2

Upstream product

• 115012-52-7 1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 
• 69304-38-7 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 58-96-8 uridine 
• 131474-62-9 1-{(2R,3R,3aR,9aR)-3-[1-(2-Fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 

Downstream Products

• 147490-77-5 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-5'-O-(9-phenylxanthen-9-yl)uridine 
• 115012-46-9 1-(2-fluorophenyl)piperidin-4-one 
• 58-96-8 uridine 
• 147490-81-1 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-5'-O-(9-phenylxanthen-9-yl)uridine 3'-<(2-cyanoethyl)-N,N-diisopropylphosphoroamidite> 
• 160905-75-9 5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)uridine 
• 160905-63-5 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-3'-O-(9-phenylxanthen-9-yl)uridine 
• 131501-59-2 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-[1-(2-fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 
• 863895-56-1 C₅₈H₆₂FN₆O₁₉P 
• 863895-59-4 C₄₃H₅₁FN₈O₂₀P₂ 
• 131474-63-0 1-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-[1-(2-fluoro-phenyl)-4-methoxy-piperidin-4-yloxy]-4-hydroxy-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione 
• 160905-61-3 5'-O-(tert-butyldiphenylsilyl)-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>uridine 

Relevant academic research and scientific papers

Acid-base and metal-ion binding properties of the RNA dinucleotide uridylyl-(5′→3′)-[5′]uridylate (pUpU3-)

It is well known that Mg2+ and other divalent metal ions bind to the phosphate groups of nucleic acids. Subtle differences in the coordination properties of these metal ions to RNA, especially to ribozymes, determine whether they either promote

Discrimination in metal-ion binding to RNA dinucleotides with a non-bridging oxygen or sulfur in the phosphate diester link

Replacement of a non-bridging oxygen in the phosphate diester bond by a sulfur has become quite popular in nucleic acid research and is often used as a probe, for example, in ribozymes, where the normally essential Mg2+ is partly replaced by a

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.

Use of the 1-(2-Fluorophenyl)-4-methoxypiperidin-4-yl (Fpmp) Protecting Group in the Solid-Phase Synthesis of Oligo- and Poly-ribonucleotides

An approach to the solid-phase synthesis of oligo- and poly-ribonucleotides is described.The synthetic strategy involves the use of building blocks in which two acid-labile groups, 1-(2-fluorophenyl)-4-methoxypiperidin-4-yl (Fpmp) and 9-phenylxanthen-9-yl