115012-46-9 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
1-(2-Fluoro-phenyl)-piperidin-4-one is used as a precursor in the synthesis of potential therapeutic agents for various medical conditions. Its unique structure and properties make it a valuable component in the development of new drugs with improved efficacy and safety profiles.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(2-Fluoro-phenyl)-piperidin-4-one serves as a versatile building block for the production of other chemical compounds. Its reactivity and functional groups allow for various chemical reactions, enabling the creation of a wide range of organic molecules with diverse applications.
Used as a Building Block for Chemical Compounds:
1-(2-Fluoro-phenyl)-piperidin-4-one is utilized as a building block in the production of other chemical compounds, particularly in the pharmaceutical and chemical industries. Its structural features and chemical properties contribute to the development of novel compounds with specific functions and applications.
Safety Precautions:
As with any chemical substance, it is crucial to observe proper handling and safety precautions when working with 1-(2-fluoro-phenyl)-piperidin-4-one. This includes following guidelines for storage, handling, and disposal to ensure the safety of individuals and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 115012-46-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,0,1 and 2 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 115012-46:
(8*1)+(7*1)+(6*5)+(5*0)+(4*1)+(3*2)+(2*4)+(1*6)=69
69 % 10 = 9
So 115012-46-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H12FNO/c12-10-3-1-2-4-11(10)13-7-5-9(14)6-8-13/h1-4H,5-8H2
115012-46-9Relevant academic research and scientific papers
Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides
Lloyd, Wayne,Reese, Colin B.,Song, Quanlai,Vandersteen, Anthony M.,Visintin, Cristina,Zhang, Pei-Zhou
, p. 165 - 176 (2007/10/03)
The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.
Facile preparation of acetals and enol ethers derived from 1-arylpiperidin-4-ones
Faja, Montserrat,Reese, Colin B.,Song, Quanlai,Zhang, Pei-Zhuo
, p. 191 - 194 (2007/10/03)
When primary aromatic amines 6 are heated under reflux with slight excesses each of crude 1,5-dichloro-pentan-3-one 4 and toluene-4-sulfonic acid monohydrate in dry methanol solution, and an excess of trimethyl orthoformate is then added to the reactants,
A New Synthesis of 1-Arylpiperidin-4-ols
Reese, Colin B.,Thompson, Elizabeth A.
, p. 2881 - 2886 (2007/10/02)
1,5-Dichloropentan-3-ol (8), which is readily prepared from the corresponding ketone (7), reacts with 2-fluoro-, 4-methyl-, 2-chloro-, 3-chloro-, 4-chloro-, and 3-chloro-4-methyl-anilines in the presence of potassium carbonate and sodium iodide in dimethy
