115012-46-9

Basic information

• Product Name: 1-(2-FLUORO-PHENYL)-PIPERIDIN-4-ONE
• Synonyms: CHEMBRDG-BB 4000324;1-(2-FLUORO-PHENYL)-PIPERIDIN-4-ONE;1-(2-FLUOROPHENYL)-4-PIPERIDINONE;AKOS MSC-0199;1-(2-fluorophenyl)piperidin-4-one(SALTDATA: FREE);1-(2-fluorophenyl)-4-piperidone;4-Piperidinone, 1-(2-fluorophenyl)-
• CAS NO: 115012-46-9
• Molecular Formula: C₁₁H₁₂FNO
• Molecular Weight: 193.22
• Mol File: 115012-46-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 309.179°C at 760 mmHg
• Flash Point: 140.787°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-FLUORO-PHENYL)-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-FLUORO-PHENYL)-PIPERIDIN-4-ONE(115012-46-9)
• EPA Substance Registry System: 1-(2-FLUORO-PHENYL)-PIPERIDIN-4-ONE(115012-46-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 115012-46-9(Hazardous Substances Data)

Usage

General Description

1-(2-Fluoro-phenyl)-piperidin-4-one is a chemical compound with the molecular formula C11H12FNO. It is a piperidinone derivative with a fluorophenyl substituent at the 1-position. 1-(2-FLUORO-PHENYL)-PIPERIDIN-4-ONE is primarily used in pharmaceutical research and drug development, particularly in the synthesis of potential therapeutic agents. It may also have applications in organic synthesis and as a building block for the production of other chemical compounds. As with any chemical substance, proper handling and safety precautions should be observed when working with 1-(2-fluoro-phenyl)-piperidin-4-one.

InChI:InChI=1/C11H12FNO/c12-10-3-1-2-4-11(10)13-7-5-9(14)6-8-13/h1-4H,5-8H2

Upstream product

• 3592-25-4 1,5-dichloropentan-3-one 
• 348-54-9 2-Fluoroaniline 
• 147490-73-1 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-2-N-(phenylacetyl)guanosine 
• 147490-71-9 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>-6-N-pivaloyladenosine 
• 147490-72-0 4-N-benzoyl-2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>cytidine 
• 115012-57-2 2'-O-<1-(2-fluorophenyl)-4-methoxypiperidin-4-yl>uridine 
• 115012-48-1 1-(2-fluorophenyl)-4,4-dimethoxypiperidine 
• 119836-08-7 1-(2-fluorophenyl)piperidin-4-ol 

Downstream Products

• 115012-48-1 1-(2-fluorophenyl)-4,4-dimethoxypiperidine 
• 1325212-02-9 (2R,3R)-2-(2,4-difluorophenyl)-3-((1-(2-fluorophenyl)piperidin-4-yl)amino)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 115012-52-7 1-(2-Fluorophenyl)-4-methoxy-1,2,5,6-tetrahydropyridine 
• 119836-13-4 1-(3-chloro-4-tolyl)piperidin-4-ol 

Relevant articles and documents

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.

A New Synthesis of 1-Arylpiperidin-4-ols

1,5-Dichloropentan-3-ol (8), which is readily prepared from the corresponding ketone (7), reacts with 2-fluoro-, 4-methyl-, 2-chloro-, 3-chloro-, 4-chloro-, and 3-chloro-4-methyl-anilines in the presence of potassium carbonate and sodium iodide in dimethy