115012-58-3

Basic information

• Product Name: 1-(3-CHLORO-PHENYL)-PIPERIDIN-4-ONE
• Synonyms: 1-(3-CHLORO-PHENYL)-PIPERIDIN-4-ONE;CHEMBRDG-BB 4000322;UKRORGSYN-BB BBV-069436;1-(3-chlorophenyl)piperidin-4-one(SALTDATA: FREE);4-Piperidinone, 1-(3-chlorophenyl)-
• CAS NO: 115012-58-3
• Molecular Formula: C₁₁H₁₂ClNO
• Molecular Weight: 209.67
• Mol File: 115012-58-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 361.2°C at 760 mmHg
• Flash Point: 172.2°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 2.11E-05mmHg at 25°C
• Refractive Index: 1.573
• PKA: 4.05±0.40(Predicted)
• CAS DataBase Reference: 1-(3-CHLORO-PHENYL)-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-PHENYL)-PIPERIDIN-4-ONE(115012-58-3)
• EPA Substance Registry System: 1-(3-CHLORO-PHENYL)-PIPERIDIN-4-ONE(115012-58-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 115012-58-3(Hazardous Substances Data)

Usage

Chemical structure

Piperidine derivative with a chlorophenyl substituent at the 3 position

Usage

Building block in the synthesis of various pharmaceuticals and agrochemicals

Pharmacological activities

Potential as an antipsychotic and antidepressant

Investigation

Potential use as a precursor or intermediate in the synthesis of other chemical compounds

Precaution

Handle with caution due to potential risks to human health and the environment if not handled properly

InChI:InChI=1/C11H12ClNO/c12-9-2-1-3-10(8-9)13-6-4-11(14)5-7-13/h1-3,8H,4-7H2

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 77542-27-9 1-benzyl-1-methyl-4-oxopiperidin-1-ium iodide salt 
• 108-42-9 3-chloro-aniline 
• 263008-83-9 2'-O-[1-(3-Chlorophenyl)-4-methoxypiperidin-4-yl]uridine 
• 41661-47-6 piperidin-4-one 
• 108-37-2 1-bromo-3-chlorobenzene 

Relevant articles and documents

Synthesis of substituted N-arylpiperidines via organobismuth derivatives

The synthesis of N-arylpiperidines functionalized both on the aromatic and piperidine ring was performed using conveniently substituted triarylbismuthine derivatives as arylating agents. This method is, in particular, indicated to arylate the nitrogen atom of a secondary amine with a phenyl ring bearing electron-withdrawing groups in the m-position.

Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2′-hydroxy functions in the chemical synthesis of oligoribonucleotides

The comparative rates of acid-catalysed removal often 1-aryl-4-methoxypiperidin-4-yl 8 (R = Me) [including the previously reported Ctmp 5 and Fpmp 6] protecting groups for the 2′-hydroxy functions in oligoribonucleotide synthesis are discussed. These studies have led to the development of the 1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl (Cpep) protecting group 8 (R = Et, R1 = R2 = H, R3 = Cl) which is both more stable than the Ctmp and Fpmp groups at pH 0.5 and more labile at pH 3.75. The influence of the ribonucleoside aglycone on the stability of the 2′-O-Fpmp and 2′-O-Ctmp protecting groups both at low and high pH is examined. The Royal Society of Chemistry 2000.