1150263-50-5Relevant academic research and scientific papers
Identification of second-generation P2X3 antagonists for treatment of pain
Ginnetti, Anthony T.,Paone, Daniel V.,Stauffer, Shaun R.,Potteiger, Craig M.,Shaw, Anthony W.,Deng, James,Mulhearn, James J.,Nguyen, Diem N.,Segerdell, Carolyn,Anquandah, Juliana,Calamari, Amy,Cheng, Gong,Leitl, Michael D.,Liang, Annie,Moore, Eric,Panigel, Jacqueline,Urban, Mark,Wang, Jixin,Fillgrove, Kerry,Tang, Cuyue,Cook, Sean,Kane, Stefanie,Salvatore, Christopher A.,Graham, Samuel L.,Burgey, Christopher S.
, p. 1392 - 1396 (2018/03/21)
A second-generation small molecule P2X3 receptor antagonist has been developed. The lead optimization strategy to address shortcomings of the first-generation preclinical lead compound is described herein. These studies were directed towards the identific
P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN
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Page/Page column 176, (2009/06/27)
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
