1150618-04-4

Basic information

• Product Name: 5-bromo-3-iodo-4-methylpyridin-2-amine
• Synonyms: 5-bromo-3-iodo-4-methylpyridin-2-amine;5-bromo-3-iodo-4-methyl-2-Pyridinamine
• CAS NO: 1150618-04-4
• Molecular Formula: C₆H₆BrIN₂
• Molecular Weight: 313
• Mol File: 1150618-04-4.mol

Chemical Properties

• Boiling Point: 316℃
• Flash Point: 145℃
• Appearance: /
• Density: 2.243
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.88±0.50(Predicted)
• CAS DataBase Reference: 5-bromo-3-iodo-4-methylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-iodo-4-methylpyridin-2-amine(1150618-04-4)
• EPA Substance Registry System: 5-bromo-3-iodo-4-methylpyridin-2-amine(1150618-04-4)

Safety Data

• Hazardous Substances Data: 1150618-04-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
5-bromo-3-iodo-4-methylpyridin-2-amine is used as a research compound for [application reason] in chemical laboratories. Its unique structure allows it to participate in various chemical reactions, making it a valuable tool for studying organic chemistry and synthesis.
Used in Pharmaceutical Development:
5-bromo-3-iodo-4-methylpyridin-2-amine is used as a building block for [application reason] in the development of new pharmaceuticals. Its structural features may contribute to the creation of novel drug candidates with potential therapeutic applications.
Used in Material Science:
5-bromo-3-iodo-4-methylpyridin-2-amine is used as a component in [application reason] for the synthesis of new materials in material science. Its properties may be harnessed to develop advanced materials with specific characteristics for various applications.

Upstream product

• 98198-48-2 2-amino-5-bromo-4-methylpyridine 

Downstream Products

• 1326216-30-1 5-bromo-4-methyl-3-((trimethylsilyl)ethynyl)pyridin-2-amine 
• 1150617-52-9 5-bromo-4-methyl-1H-pyrrolo[2,3-b]pyridine 
• 1538609-66-3 {3-[6-[2-(4-cyano-phenyl)-2H-pyrazol-3-yl]-7-methyl-8-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylcarbamoyl]-propyl}-methyl-carbamic acid tert-butyl ester 

Relevant articles and documents

Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis

Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty. Historically, the lack of economic incentive to develop new treatments for these diseases has meant that existing therapeutics have serious shortcomings in terms of safety, efficacy, and administration, and better therapeutics are needed. We now report a series of 3,5-disubstituted-7-azaindoles identified as growth inhibitors of Trypanosoma brucei, the parasite that causes HAT, through a high-throughput screen. We describe the hit-to-lead optimization of this series and the development and preclinical investigation of 29d, a potent antitrypanosomal compound with promising pharmacokinetic (PK) parameters. This compound was ultimately not progressed beyond in vivo PK studies due to its inability to penetrate the blood-brain barrier (BBB), critical for stage 2 HAT treatments.

[1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

IMIDAZOPYRIDIN-2-ONE DERIVATIVES

A compound represented by formula (I) having mTOR inhibitory activity or a pharmacologically acceptable salt thereof.