115085-90-0Relevant academic research and scientific papers
Access to 2-alkyl chromanones via a conjugate addition approach
Stubbing, Louise A.,Li, Freda F.,Furkert, Daniel P.,Caprio, Vittorio E.,Brimble, Margaret A.
, p. 6948 - 6956 (2012/09/07)
The introduction of alkyl substituents at C-2 of chromanones via conjugate addition of silyl enol ethers to a variety of chromenones is reported. In most cases racemic 2-alkyl chromanones were obtained in good yield in the presence of TMSOTf. The copper(II)-promoted conjugate addition of silyl enol ethers to chromenones was also carried out, albeit in low yields and no selectivity. Reliable syntheses of the chromenones via acylation of the corresponding β-diketo-compounds are also described.
One-pot reaction of ortho-acylphenols and terminal alkynoates for synthesis of 2-alkyl-substituted chromanones
Meng, Ling-Guo,Liu, Hui-Fang,Wei, Jian-Long,Gong, Sun-Na,Xue, Song
experimental part, p. 1748 - 1750 (2010/05/18)
A facile synthesis of 2-alkyl-substituted chromanones from ortho-acylphenols and terminal alkynoates is described. The method contains two consecutive processes in one-pot reaction through a DABCO-catalyzed condensation reaction and a KOBut-mediated intramolecular cycloaddition to afford the desired products.
REACTION OF 4-t-BUTYLDIMETHYLSILOXY-1-BENZOPYRYLIUM SALT WITH ENOL SILYL ETHERS AND ACTIVE METHYLENES
Iwasaki, Hideharu,Kume, Takashi,Yamamoto, Yohsuke,Akiba, Kin-ya
, p. 6355 - 6358 (2007/10/02)
4-t-Butyldimethylsiloxy-1-benopyrylium salt (2) was prepared in situ from chromone (1) and t-butyldimethylsilyl triflate and the salt reacted with enol silyl ethers, ketene silyl acetals and active methylene compounds to afford 2-substituted 4-t-butyldime
