936182-86-4Relevant academic research and scientific papers
SUBSTITUTED CHROMANES AND METHOD OF USE
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Page/Page column 250, (2016/05/19)
The invention provides for compounds of formula (I), wherein R1, X, Y, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, m, and R" have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
Access to 2-alkyl chromanones via a conjugate addition approach
Stubbing, Louise A.,Li, Freda F.,Furkert, Daniel P.,Caprio, Vittorio E.,Brimble, Margaret A.
experimental part, p. 6948 - 6956 (2012/09/07)
The introduction of alkyl substituents at C-2 of chromanones via conjugate addition of silyl enol ethers to a variety of chromenones is reported. In most cases racemic 2-alkyl chromanones were obtained in good yield in the presence of TMSOTf. The copper(II)-promoted conjugate addition of silyl enol ethers to chromenones was also carried out, albeit in low yields and no selectivity. Reliable syntheses of the chromenones via acylation of the corresponding β-diketo-compounds are also described.
Catalytic enantioselective synthesis of flavanones and chromanones
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Page/Page column 14, (2009/10/21)
Various chromanone, flavanone and abyssinone compounds as can be prepared enantioselectively using a chiral thiourea catalyst.
Catalytic enantioselective synthesis of flavanones and chromanones
Biddle, Margaret M.,Lin, Michael,Scheidt, Karl A.
, p. 3830 - 3831 (2008/02/04)
The enantioselective synthesis of flavanones and chromanones is described. Bifunctional thiourea catalysts promote an asymmetric oxo-conjugate addition to a β-ketoester alkylidene in high yields with excellent enantioselectivity (80-94% ee) for aryl and alkyl substrates. Decarboxylation of the β-ketoester proceeds smoothly in a one-pot procedure to afford the enantioenriched flavanones and chromanones. Copyright
