115088-06-7

Basic information

• Product Name: SPDB
• Synonyms: SPDB;2,5-dioxopyrrolidin-1-yl 4-(pyridin-2-yldisulfanyl)butanoate;SPDB crosslinker
• CAS NO: 115088-06-7
• Molecular Formula: C13H14N2O4S2
• Molecular Weight: 326.39126
• Mol File: 115088-06-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: SPDB(CAS DataBase Reference)
• NIST Chemistry Reference: SPDB(115088-06-7)
• EPA Substance Registry System: SPDB(115088-06-7)

Safety Data

• Hazardous Substances Data: 115088-06-7(Hazardous Substances Data)

Usage

General Description

SPDB, or N-succinimidyl 3-(2-pyridyldithio)propionate, is a heterobifunctional crosslinker commonly used in protein-protein conjugation and antibody labeling. SPDB contains a pyridyldithiol group and a succinimidyl ester group, allowing it to react with both protein thiol groups and amine groups. SPDB is often used to link antibodies to other proteins or to label proteins with fluorescent or biotin tags. It is water-soluble and reacts rapidly under mild conditions, making it a versatile and widely used chemical in the field of bioconjugation and protein labeling.

Upstream product

• 74124-79-1 di(succinimido) carbonate 
• 1229158-84-2 C₉H₁₁NO₂S₂*C₁₂H₂₃N 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 250266-79-6 4-(pyridin-2-yldisulfanyl)butanoic acid 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 

Relevant articles and documents

BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Semisynthetic Maytansine analogues for the targeted treatment of cancer

Maytansine, a highly cytotoxic natural product, failed as an anticancer agent in human clinical trials because of unacceptable systemic toxicity. The potent cell killing ability of maytansine can be used in a targeted delivery approach for the selective destruction of cancer cells. A series of new maytansinoids, bearing a disulfide or thiol substituent were synthesized. The chain length of the ester side chain and the degree of steric hindrance on the carbon atom bearing the thiol substituent were varied. Several of these maytansinoids were found to be even more potent in vitro than maytansine. The targeted delivery of these maytansinoids, using monoclonal antibodies, resulted in a high, specific killing of the targeted cells in vitro and remarkable antitumor activity in vivo.